Functional role of symmetric and asymmetric STDP rules in sequence learning in the brain

对称和不对称 STDP 规则在大脑序列学习中的功能作用

• 批准号: 19500126
• 负责人: HAYASHI Hatsuo
• 金额: $ 2.83万
• 依托单位: Kyushu Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500126/
• 关键词: 嗅内皮質; 神経回路網モデル; 時系列学習; 海馬歯状回; 顆粒細胞モデル; シナプス競合; STDP学習ルール; シナプス間競合; LTDウインドウ; 感覚情報統合

We investigated roles of symmetric and asymmetric STDP learning rules in sequence learning in the entorhinal cortex and the hippocampus. It was elucidated that the symmetric STDP learning rule was suitable for establishing a sequence of loop connections, which represented a sequence of places, amid background noise. In contrast, the asymmetric STDP learning rule was suitable for synaptic competition to select spatial information accompanied by valuable non-spatial information such as odor and to cause directional propagation of neuronal activity in the hippocampal CA3 network. These results suggest that it is important to consider what STDP learning rules are suitable for local network structures in order to unveil mechanisms of the sequence learning in the whole system consisting of the hippocampus and the entorhinal cortex.

我们研究了对称和非对称STDP学习规则在内嗅皮层和海马的顺序学习中的作用。说明了对称STDP学习规则适用于在背景噪声条件下建立代表位置序列的环路连接序列。而非对称STDP学习规则则适用于突触竞争选择空间信息（如气味等有价值的非空间信息），并引起海马CA3网络神经元活动的定向传播。这些结果表明，为了揭示由海马和内嗅皮层组成的整个系统的序列学习机制，考虑哪些STDP学习规则适合局部网络结构是很重要的。

项目成果

リカレントネットワークにおける抑制領域の違法性による興奮伝導の制御

通过循环网络中抑制区域的非法性来控制兴奋性传导

• 发表时间: 2010
• 作者: 佐村俊和;林初男
• 通讯作者: 林初男

Theta phase coding and suppression of irregular plastic change through STDP in the entorhino-hippocampal system amid background noise. in“Advances in Cognitive Neurodynamics, "

背景噪声中内鼻海马系统中的 Theta 相位编码和 STDP 抑制不规则塑性变化，《认知神经动力学进展》。

• 发表时间: 2008
• 作者: Jun Igarashi;Hatsuo Hayashi
• 通讯作者: Hatsuo Hayashi

Emergence of sequence sensitivity in a hippocampal CA3-CA1 model.

海马 CA3-CA1 模型中序列敏感性的出现。

• 发表时间: 2007
• 期刊: Neural Networks Vol.20
• 作者: Motoharu Yoshida;Hatsuo Hayashi
• 通讯作者: Hatsuo Hayashi

Theta phase coding and suppression of irregular plastic change through STDP in the entorhino-hippocampal system amid background noise

背景噪声下内鼻海马系统中的 Theta 相位编码和 STDP 抑制不规则塑性变化

• 发表时间: 2007
• 作者: Jun Igarashi;Hatsuo Hayashi
• 通讯作者: Hatsuo Hayashi

Theta phase coding and suppression of irrelevant plastic change through STDP in the entorhinal-hippocampal system amid background noise.

背景噪声下的内嗅海马系统中的 Theta 相位编码和通过 STDP 抑制不相关的塑性变化。

• 发表时间: 2008
• 期刊: Advances in Cognitive Neurodynamics
• 作者: Jun Igarashi;Hatsuo Hayashi
• 通讯作者: Hatsuo Hayashi