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Selective Perfusion Imaging with Intravenous Myocardial Contrast Echocardiography

静脉内心肌造影超声心动图选择性灌注成像

基本信息

批准号：
15300183
负责人：
BEPPU Shintaro
金额：
$ 4.54万
依托单位：
Osaka University, Graduate School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15300183/
关键词：
Ultrasound Contrast Microbubble Contrast Echo Perfusion Imaging Selective

项目摘要

Background : Intravenous myocardial contrast echocardiography (MCE) cannot identify each perfusion area of coronary vessels separately. However, by destroying microbubbles passing through a specific vessel using high-power ultrasound during intravenous MCE, vessel-selective perfusion imaging (VSPI) may he feasible.Methods : In 10 open-chest dogs, intermittent short-axis images were obtained during Definity infusion using a Sequoia 512 system. For VSPI, an S3 probe coupled to a Sonos 5500 was placed on the proximal left circumflex(LCx) artery. High-power ultrasound pulses were transmitted to destroy bubbles passing through the LCx artery. A negative contrast area on VSPI was considered to represent the perfusion area of the LCx artery (LCx-VSPI). A negative contrast area on conventional MCE during LCx occlusion (LCx-Occ) and a region without staining by Evans blue dye (LCx-EB) were used as gold standards for defining the LCx perfusion area. LCx-VSPI was compared with LCx-Occ and LCx-EB.Results : Despite lack of LCx artery occlusion, high-power destructive pulses produced a definite area of negative contrast on the LCx region. Decreased power of ultrasound pulses resulted in disappearance of the negative contrast area. An excellent relationship was demonstrated between both LCx-VSPI and LCx-Occ (r=0.93,P<.0001), and LCx-VSPI and LCx-EB (r=0.92,P=.0002).Conclusion : VSPI during intravenous MCE may be feasible for noninvasive assessment of perfusion areas associated with specific vessels.

背景：静脉心肌超声造影（MCE）不能单独识别冠状血管的各个灌注区域。然而，在静脉MCE期间，通过使用高功率超声破坏通过特定血管的微泡，血管选择性灌注成像（VSPI）可能是可行的。方法：在10只开胸犬中，使用Sequoia 512系统在Definity输注期间获得间歇性短轴图像。对于VSPI，将S3探针连接Sonos 5500放置在左旋动脉近端。通过高功率超声脉冲来破坏通过左动脉的气泡。认为VSPI上的阴性对比区代表LCx动脉的灌注区（LCx-VSPI）。LCx闭塞时常规MCE阴性对比区（LCx- occ）和未染Evans蓝染色区（LCx- eb）作为定义LCx灌注区域的金标准。LCx-VSPI与LCx-Occ和LCx-EB进行比较。结果：尽管LCx动脉没有闭塞，但高功率破坏性脉冲在LCx区域产生了明确的负对比。超声脉冲功率降低导致负对比区消失。LCx-VSPI与LCx-Occ呈极好的相关性（r=0.93，P< 0.0001）， LCx-VSPI与LCx-EB呈极好的相关性（r=0.92，P= 0.0002）。结论：静脉MCE时VSPI对特定血管相关灌注区无创评估是可行的。