Study on micro-dynamics in the micro-fluidic devises

微流控装置中的微动力学研究

• 批准号: 15360092
• 负责人: OKAMOTO Koji
• 金额: $ 8.32万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15360092/
• 关键词: Micro-PIV; High-speed Micro PI; Counter current flow; Non-linear diffusion; Transient flow field; Micro-LIF; Micro-dynamics; マイクロマシン; マイクロTAS; 速度場計測; pH分布計測

The micro-PIV system and the micro-LIF system had been developed and applied to the micro-fluidics, such as the Micro-TAS (Total Analysis System), Lab-on-chip, and so on. It is very important to know the field information to fabricate the effective fluidic devises. The velocity field and the pH fields are quantitatively measured using the developed systems.In the Micro-LIF system, the pH distributions inside the micro-channel had been clearly visualized using the microscope and fluorescent dye. With analyzing the pH distributions, the non-linear enhancement of diffusions are clearly shown for the mixing process of micro-fluidic devises.In the Micro-PIV system, the super-resolution high-speed camera with Image Intensifier had been applied to visualize the micro flow using the CW laser and microscope. The resolution of the images is 1024x1024 pixel with 2000 frame per second. The size of the channel is only 100micro-m. Counter current flow with oil and water are realized using the X-type … More channel. At the interface of the oil and water inside the micro-channel, the unsteady micro-vortex is clearly visualized. This phenomenon has never reported before. Because of the high-temporal-resolution of the high-speed camera with high-spatial-resolution can realize such kind of transient flow field inside the micro-channel. The discovered micro-vortex may affect on the non-linear diffusion or non-linear mixing at the interface.We have developed the micro-PIV/LIF system to analyze the micro-dynamics of the micro-fluidic devises. The measured results clearly indicate the existence of non-linear flow dynamics at the interface. It is well-known that the interfacial forces plays most important role under the micro-fluidic devises, because of the micro-scale. The non-linear interfacial phenomena cause the non-linear flow fields, such as, non-linear diffusion and micro-vortex. The discovery of the non-linear dynamics in the micro-fluidic devises is very important to understand the micro-flow dynamics. Also, the developed micro-PIV/LIF systems will be strong tools to investigate the micro-dynamics. Less

微流场PIV系统和微流场LIF系统已经发展并应用于微流控领域，如微TAS（Total Analysis System）、芯片实验室（Lab-on-chip）等，了解微流场信息对于设计有效的微流控器件具有重要意义。在Micro-LIF系统中，利用显微镜和荧光染料可以清晰地观察到微通道内的pH值分布。通过对pH值分布的分析，揭示了微流控装置混合过程中扩散的非线性增强现象。在Micro-PIV系统中，利用连续激光器和显微镜，采用带图像增强器的超分辨率高速摄像机对微流场进行了可视化。图像的分辨率为1024 x1024像素，每秒2000帧。通道的尺寸仅为100微米。使用X型实现油和水的逆流流动 ...更多信息 频道在微通道内的油水界面处，可以清晰地看到非稳态的微涡。这种现象以前从未报道过。由于高速摄像机的高时间分辨率和高空间分辨率，可以实现对微通道内瞬态流场的实时监测。微涡旋的发现可能会影响界面处的非线性扩散或非线性混合。我们开发了微PIV/LIF系统来分析微流控器件的微观动力学。测量结果清楚地表明在界面处存在非线性流动动力学。由于微尺度的关系，微流体系统中的界面力是影响系统性能的主要因素。非线性的界面现象导致了非线性的流场，如非线性扩散和微涡。微流控器件中非线性动力学的发现对于理解微流控系统的动力学具有重要意义。此外，开发的micro-PIV/LIF系统将成为研究微观动力学的有力工具。少

项目成果

Quantitative visualization of micro-tube flow using micro-PIV

• DOI: 10.1007/bf03181480
• 发表时间: 2004
• 期刊: Journal of Visualization
• 影响因子: 1.7
• 作者: Y. Sugii;K. Okamoto

Sugii Y: "Quantitative Visualization of Micro-Tube Flow Using Micro-PIV"Journal of Visualization. 7・1. 9-16 (2004)

Sugii Y：“使用 Micro-PIV 的微管流动的定量可视化”可视化杂志 7・1（2004 年）。

Rapid proton diffusion in microfluidic devices by means of micro-LIF technique

通过 micro-LIF 技术在微流体装置中快速质子扩散

• 发表时间: 2005
• 期刊: Experiment in Fluids 38
• 作者: K.Shinohara;Y.Sugii;A.Hibara;M.Tokeshi;T.Kitamori;K.Okamoto
• 通讯作者: K.Okamoto

Measurement of pH field of chemically reacting flow in microfluidic device by laser induced fluorescence

激光诱导荧光测量微流控装置中化学反应流的pH场

• 发表时间: 2004
• 期刊: Measurement Science and Technology 15
• 作者: K.Shinohara;Y.Sugii;K.Okamoto;H.Madarame;A.Hibara;M.Tokeshi;T.Kitamori
• 通讯作者: T.Kitamori

Shinohara K: "Measurement of pH field of chemically reacting flow in microfluidic device by laser induced fluorescence"Measurement Science and Technology. (印刷中). (2004)

Shinohara K：“通过激光诱导荧光测量微流体装置中化学反应流的pH场”测量科学与技术（2004年出版）。