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Genome-wide screen and functional analysis of novel factors required for selective degradation of mitochondria

Genome-wide screen and functional analysis of novel factors required for selective degradation of mitochondria
线粒体选择性降解所需新因子的全基因组筛选和功能分析
批准号:
20570144
负责人:
OKAMOTO Koji
金额:
$3.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Mitochondria serve as "the power plants of the cell", playing essential roles in cellular functions. Recently, it has been proposed that degradation of mitochondria as whole organelles, termed mitophagy, is critical for mitochondrial quality control. However, the molecular mechanisms remain largely unknown. In this study, we utilized budding yeast, and succeeded to establish selective degradation of mitochondria as a phenomenon to be analyzed, and systematically identify mitophagy-related factors.
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会议论文
選択的ミトコンドリア分解:現象から分子理解へ
选择性线粒体降解:从现象到分子理解
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ya-Jen Chang, et al., 岡本浩二]
通讯作者: 岡本浩二
Regulation of mitochondria-specific degradation in yeast.
酵母中线粒体特异性降解的调节。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [光武進, 他, 岡本浩二]
通讯作者: 岡本浩二
Molecular basis of mitochondrial degradation via selective autophagy in yeast
酵母选择性自噬降解线粒体的分子基础
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [岡本浩二, 岡本徳子, 高橋郁子, 大隅良典]
通讯作者: 大隅良典
ミトコンドリア分解を司る選択的オートファジーの制御機構
选择性自噬调控线粒体降解的控制机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Masafumi Inoue, Takashi Konno, Kazuki Tainaka Eiji Nakata Hiro-o Yoshida Takashi Morii, Michio Shimamura, 岡本浩二]
通讯作者: 岡本浩二
22
    Investigation of shear force pump design for efficiency improvement and its miniaturization
    • 批准号:
      26420808
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2014
    • 负责人:
      OKAMOTO Koji
    • 依托单位:
    Regulatory mechanisms and molecular bases of selective mitochondria degradation
    • 批准号:
      25291045
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.56万
    • 财政年份:
      2013
    • 负责人:
      OKAMOTO Koji
    • 依托单位:
    Generation of an eukaryote harboring genes transferred from mitochondria to the nucleus
    • 批准号:
      25650067
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.58万
    • 财政年份:
      2013
    • 负责人:
      OKAMOTO Koji
    • 依托单位:
    Establishmentof tools regulating mitophagyby chemical biology
    • 批准号:
      23657090
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.58万
    • 财政年份:
      2011
    • 负责人:
      OKAMOTO Koji
    • 依托单位:
    海外基金