Circuit simulation of working memory control by dopamine

多巴胺控制工作记忆的电路模拟

• 批准号: 15500218
• 负责人: TANAKA Shoji
• 金额: $ 2.11万
• 依托单位: Sophia University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500218/
• 关键词: Schizopherenia; Prefrontal cortex; Cognitive function; Glutamate; Dopamine; D1 receptor; Instability; Working memory; 神経回路; モデル; D1受容体; D2受容体; 中脳ドーパミン; 認知; モジュレーション; 回路モデル; シミュレーション

I did theoretical analysis and computer simulations of working memory control by dopamine. New models are constructed and a new theory is proposed. The study is devoted to the functions of D1 and D2 receptors. First, how dopamine changes the stability of working memory representation via D1 receptor activation has been explored. This study suggests that dopamine do not only change the robustness of working memory representation, as was suggested previously, but alter fundamental cognitive operations so that various kinds of operations can be performed. Second, by analyzing the dynamical characteristics of the dopaminergic modulatory system, this study elucidated the functions of the dopaminergic system regarding cognitive control. The dynamics is suggested to have different characteristics depending on the extracelullar dopamine concentration in the prefrontal cortex. Finally, I propose a new theory on schizophrenia, that is "the stability theory of schizophrenia". This theory states that the network for cognitive operations tends to be unstable under hypoglutamatergic conditions. This theory can account for not only the decrement of dopamine concentration in the prefrontal cortex but abnormal activation of the prefrontal cortex, which has often been observed by functional imaging studies while the patients with schizophrenia performed cognitive tasks. This theory should be applied to psychiatric research.

我做了多巴胺控制工作记忆的理论分析和计算机模拟。建立了新的模型，提出了新的理论。本研究致力于D1和D2受体的功能。首先，研究了多巴胺如何通过D1受体激活改变工作记忆表征的稳定性。这项研究表明，多巴胺不仅改变了工作记忆表征的稳健性，而且改变了基本的认知操作，使各种操作能够进行。其次，通过分析多巴胺能调节系统的动力学特性，阐明了多巴胺能系统在认知控制方面的功能。根据前额叶皮层的胞外多巴胺浓度，这种动态具有不同的特征。最后，笔者提出了一种新的精神分裂症理论，即“精神分裂症稳定性理论”。该理论指出，认知操作网络在低谷氨酸条件下趋于不稳定。这一理论不仅可以解释前额皮质多巴胺浓度的下降，还可以解释前额皮质的异常激活，这在精神分裂症患者执行认知任务时经常被功能成像研究观察到。这一理论应该应用于精神病学研究。

项目成果

(2005) Dopaminergic control of working memory and its relevance to schizophrenia : a circuit dynamics perspective.[Review]

(2005) 工作记忆的多巴胺能控制及其与精神分裂症的相关性：电路动力学视角。[评论]

• 发表时间: 2005
• 期刊: Neuroscience (in press)
• 作者: Tanaka S

Noradrenergic control of multi-target spatial working memory.

多目标空间工作记忆的去甲肾上腺素能控制。

• 发表时间: 2004
• 期刊: Neuroscience Research : Abstracts of the 27th Annual Meeting of the Japan Neuroscience Society (21-23 Sep 2004, Osaka). 50 Supplement 1, S203
• 作者: Nishijima Y;Tanaka S
• 通讯作者: Tanaka S

Tabuchi Y, Tanaka S: "Intracortical vs thalamocortical processing of spatial wanting memory"Neurocomputing. 52-54. 403-409 (2003)

Tabuchi Y、Tanaka S：“空间需求记忆的皮质内与丘脑皮质处理”神经计算。

Circuit simulation of the mesocorticolimbic system.

中皮质边缘系统的电路模拟。

• 发表时间: 2004
• 期刊: Neuroscience Research : Abstracts of the 27th Annual Meeting of the Japan Neuroscience Society (21-23 Sep 2004, Osaka). 50 Supplement 1, S148
• 作者: Nagai H;Tanaka S
• 通讯作者: Tanaka S

Cortico-thalamocortical operations of multi-target spatial working memory.

多目标空间工作记忆的皮质-丘脑皮质操作。

• 发表时间: 2003
• 期刊: Neurocomputing 52-54
• 作者: Miyashita S;Tabuchi Y;Tanaka S
• 通讯作者: Tanaka S