Lateralization and hemispheric interaction during auditory processing in children with ADHD

多动症儿童听觉处理过程中的偏侧化和半球相互作用

• 批准号: 463335191
• 负责人: Dr. Nicole Angenstein
• 金额: --
• 依托单位: Combinatorial NeuroImaging Core Facility (CNI)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/463335191?language=en
• 关键词: Lateralization; hemispheric; interaction; during; auditory

Many children with attention-deficit/hyperactivity disorder (ADHD) also suffer from auditory processing deficits and have a higher risk of language problems. Maladapted lateralization of auditory processing and changes of interhemispheric interaction in children with ADHD may play a major role since the processing of complex auditory stimuli like speech requires a well-functioning division of labor between the left and right auditory cortex and an efficient interaction between hemispheres. This again requires a normally developed brain anatomy. It is not known how differences in hemispheric asymmetries and hemispheric interaction are actually related to impaired auditory processing in children with ADHD. The purpose of the proposed project is to characterize differences in lateralization and interhemispheric interaction during auditory processing in children with ADHD compared to normally developing children. The aim is to reveal the link between functional and anatomical alterations in children with ADHD and their often-observed deficits in auditory processing. First, the abilities of children with ADHD to discriminate basic acoustic parameters will be determined. In addition, more complex auditory capabilities will be tested by using two types of tasks that differentially involve the left and right auditory cortex and hence require a different amount of hemispheric interaction (categorization and comparison of direction of pitch change). The lateralization of activity and the interhemispheric interaction during the categorization and the comparison task will be investigated by using functional magnetic resonance imaging (fMRI) whereas electroencephalography (EEG) will be used to assess the temporal dynamics of hemispheric interaction. Furthermore, macro- and microanatomical properties of the auditory cortex and of the corpus callosum as the interhemispheric connection will be explored by using anatomical MRI and diffusion tensor imaging (DTI). The connection between behavioral, functional and anatomical measurements will provide a more thorough understanding of auditory processing deficits in children with ADHD, which may also have implications for symptoms like inattention and poor behavioral control. The understanding of the auditory processing deficits may in the future help to develop training strategies or interventions to overcome these impairments by changing hemispheric interaction and/or the lateralization of processing.

许多患有注意力缺陷/多动障碍（ADHD）的儿童也患有听觉处理缺陷，并且有更高的语言问题风险。ADHD儿童听觉处理的不适应偏侧化和半球间互动的变化可能起着重要作用，因为复杂的听觉刺激（如语音）的处理需要左右听觉皮层之间功能良好的分工和半球之间的有效互动。这又需要一个正常发育的大脑解剖结构。目前尚不清楚大脑半球不对称性和大脑半球相互作用的差异与ADHD儿童听觉处理受损的实际关系。拟议项目的目的是表征偏侧化和大脑半球间的相互作用在听觉处理ADHD儿童相比，正常发育的儿童的差异。其目的是揭示ADHD儿童的功能和解剖学改变与他们经常观察到的听觉处理缺陷之间的联系。首先，ADHD儿童辨别基本声学参数的能力将被确定。此外，更复杂的听觉能力将通过使用两种类型的任务进行测试，这两种任务分别涉及左右听觉皮层，因此需要不同数量的半球互动（分类和比较音高变化的方向）。活动的偏侧化和半球间的相互作用在分类和比较任务将通过使用功能性磁共振成像（fMRI），而脑电图（EEG）将被用来评估半球的相互作用的时间动态进行了研究。此外，宏观和微观解剖特性的听觉皮层和胼胝体的半球间的连接将探讨通过使用解剖MRI和扩散张量成像（DTI）。行为，功能和解剖测量之间的联系将为ADHD儿童的听觉处理缺陷提供更全面的了解，这也可能对注意力不集中和行为控制不良等症状产生影响。对听觉处理缺陷的理解可能有助于在未来制定训练策略或干预措施，以克服这些障碍，通过改变半球的相互作用和/或加工的偏侧化。