HEMISPHERIC SPECIALIZATION AND INTERACTION

这是一个五年更新的NIH拨款的请求， 关于半球的专业化和相互作用的界面， 语言与认知 一个收敛的研究计划概述 该研究研究神经系统患者和正常受试者， 结合了行为学和解剖学的方法 技术发展包括一个强大的基于计算机的 偏侧性研究实验室和带暗点眼动仪 半球眼扫描模拟器 the eye. 理论工作将继续对行为模型， 平行独立的偏侧效应和条件 在两个半球中处理。 其中一组实验将研究独立的词汇通达， 组织、句法和语用能力以及相关的 两个半球的认知能力，包括 学习新语言材料并监控和纠正的能力 错误. 同时，其他实验将研究半球 处理和监控非语言任务的独立性， 包括视觉图像，视觉错觉，面部识别， 对象分类 另一组实验将分析个体差异， 胼胝体连接的区域模式， 解剖测量，特别是与认知概况有关的测量。 改变胼胝体的生物和环境条件 将研究连通性。 神经病理切片 将胼胝体与MRI测量值进行比较，并用于计数 不同地区的不同类型的纤维。 结果保证更好地理解和可能的控制 认知病理学由于异常的大脑激活或错误的 大脑半球间的交流 这些数据将有助于 理论认知神经科学通过理解语言 是如何在大脑中组织起来的， 处理模块相互作用。

This is a request for a five year renewal of an NIH grant focusing on hemispheric specialization and interaction at the interface of language and cognition. A convergent research program is outlined which studies neurological patients and normal subjects and combines behavioral and anatomical methods. Technological developments include a powerful computer-based laboratory for laterality research and an eye-tracker with scotoma simulator for hemispheric ocular scanning without attachments to the eye. Theoretical work will continue on behavioral models of laterality effects and conditions for parallel independent processing in the two hemispheres. One set of experiments will study independent lexical access and organization, syntactic and pragmatic competence and associated cognitive abilities in each of the two hemispheres, including the ability to learn new linguistic material and to monitor and correct errors. In parallel, other experiments will study hemispheric independence in processing and monitoring nonverbal tasks, including visual imagery, visual illusions, face recognition, and object classification. Another set of experiments will analyze individual differences in regional patterns of callosal connectivity using behavioral and anatomical measures, especially in relation to cognitive profile. Biological and environmental conditions that change callosal connectivity will be investigated. Neuropathological sections of the callosum will be compared to MRI measures, and used to count fibers of different types in several regions. Results promise better understanding and possible control of cognitive pathology due to abnormal cerebral activation or faulty interhemispheric communication. The data will contribute to theoretical cognitive neuroscience by understanding how language is organized in the brain and how independent, parallel cortical processing modules interact.