Theoretical design of taste masking for amino acid or basic drugs using a taste sensor

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The purpose of this study was to develop a quantitative prediction method for the determination of the bitterness of solutions containing amino acids or medicines using a multichannel taste sensor.In related to amino acids, we focused on taste of elemental diets. We quantitively evaluate the bitterness of various concentrated of various type of amino acids such as BCAA : L-isoleucine, L-leucine, L-valine.In related to palatability for them, intensities for various palatability scales were measured. The addition of flavors was so effective in reducing the bitterness intensities of BCAA solutions since organic acid was the most effective for reducing the bitterness. (reference No.1) Whereas the bitterness or saltiness was negatively correlated with total palatability (reference No.2).The antibiotics which are basic medicines, taste, the bitterness of pediatric medicines were evaluated by sensor measurement. The predicted data was correlated with obtained value in gustatory sensation result and bitterness enhancement of dry syrup could be predicted by taste sensor usage (reference No.3).In the case of commercial nutritive drinks which containing thiamine or herbal medicine ingredients, obtained value in human gustatory sensation could be predicted by taste sensor (reference No.4). Thus the usefulness of taste sensor was demonstrated in prediction of basic medicines or amino acids.