Studies on the Distribution of Japanese Strain of Spotted Fever Group Rickettsiae in China

斑疹热群立克次体日本株在我国的分布研究

• 批准号: 01044104
• 负责人: UCHIDA Takahiro
• 金额: $ 3.9万
• 依托单位: The University of Tokushima, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01044104/
• 关键词: Rickettsia japonica; Rickettsia typhi; spotted fever group rickettsia; biogeographic region; Oriental region; China Hainan Island; Shandong Province; 山東省

Infections with Rickettsia Japonica, a newly identified spotted fever group (SFG) rickettsia, were recognized mostly in the southwestern part of Japan facing the Pacific Ocean. It has been known that the various species of SFG rickettsiae occur in geographically distinct regions (biogeographic regions) separated for the most part by natural boundaries. The present study was designed to find the distribution of R. japonica in the Oriental region. Serologic surveys for antibodies to R. Japonica were conducted on Hainan Island in the southern part of China and also in Shandong Province of the eastern edge. Total of 499 serum specimens were collected from hospitals located in the northern, eastern, central, western, and southern parts of Hainan Island. Only one among 107 serum specimens collected in the southern part was found to contain antibodies reactive with R. Japonica at a high titer. Further survey also showed that one out of 331 serum specimens collected in the southern Hainan Island contained antibodies reactive with R. Japonica. The results indicated a possibility of the existence of a SFG rickettsiosis on the island, although its incidence seems to be very low. R. Japonica is likely to be a candidate for the causative agent, but the positive proof needs to isolate and identify the agent. Up to the present, the isolation of a SFG rickettsia has been performed without success. The present study also demonstrated a high incidence of murine typhus on Hainan Island. About 2.7 to 12% of serum specimens collected in the southern part reacted with R. Typhi, a half of which contained IgM antibodies, Furthermore, more than 60% of suspected rickettsial infections were murine typhus. In Shandong province, on the other hand, 1100 serum specimens were tested, demonstrating that 3 among 500 specimens from a hospital in Jinan city contained low titers of antibodies reactive with R. Japonica.

日本立克次体（Rickettsia Japonica）是一种新发现的斑点热群（SFG）立克次体，主要在面向太平洋的日本西南部地区发现感染。已知SFG立克次体的不同种存在于地理上不同的区域（地理区域），这些区域大部分由自然边界隔开。本研究的目的是寻找R.日本在东方地区。血清学调查的抗体R。粳稻在中国南部的海南岛和东部边缘的山东省进行了试验。从海南岛北方、东部、中部、西部和南部的医院共采集血清标本499份。在南部地区采集的107份血清标本中，仅发现1份含有与R反应的抗体。日本在一个高滴度。海南岛南部地区331份血清标本中有1份血清中含有抗红细胞链球菌抗体。日本结果表明，岛上可能存在SFG立克次体病，尽管其发病率似乎很低。R.粳稻可能是病原菌的候选者，但阳性证据需要分离鉴定病原菌。到目前为止，SFG立克次体的分离一直没有成功。本研究还证实了海南岛斑疹伤寒的高发病率。南部地区约有2.7 ~ 12%的血清标本与R.伤寒，其中一半含有IgM抗体，此外，超过60%的可疑立克次体感染是鼠伤寒。山东省1100份血清标本检测结果表明，济南市某医院500份血清标本中，有3份血清标本的抗体滴度较低。日本

项目成果

Feng Huiーmin et al.: "Serologic survey of spotted fever group tickettsiosis on Hainan Island of China" Microbiology and Immunology.

冯惠民等：“中国海南岛斑疹热群票虫病血清学调查”微生物学与免疫学。

Uchiyama, T., Uchida, T., and Walker, D. H.: "Species-specific monoclonal antibodies to Rickettsia japonica, a newly identified spotted fever group rickettsia" Journal of clinical Microbiology. 28. 1177-1180 (1990)

Uchiyama, T.、Uchida, T. 和 Walker, D. H.：“针对日本立克次体的物种特异性单克隆抗体，一种新发现的斑点热群立克次体”《临床微生物学杂志》。

Uchiyama Tsuneo et al.: "SPeciesーspecific monoclonal antibodies to Reckettsia japonica,a newly identified spotted fever group rickettsia" Journal of Clinical Microbiology. 28. 1177-1180 (1990)

Uchiyama Tsuneo 等人：“针对日本立克次体（一种新发现的斑疹热群立克次体）的物种特异性单克隆抗体”临床微生物学杂志 28. 1177-1180 (1990)。