Studies on the Distribution of Japanese Strain of Spotted Fever Group Rickettsiae in China

斑疹热群立克次体日本株在我国的分布研究

基本信息

批准号：
01044104
负责人：
UCHIDA Takahiro
金额：
$ 3.9万
依托单位：
The University of Tokushima, School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01044104/
关键词：
Rickettsia japonica Rickettsia typhi spotted fever group rickettsia biogeographic region Oriental region China Hainan Island Shandong Province 山東省

项目摘要

Infections with Rickettsia Japonica, a newly identified spotted fever group (SFG) rickettsia, were recognized mostly in the southwestern part of Japan facing the Pacific Ocean. It has been known that the various species of SFG rickettsiae occur in geographically distinct regions (biogeographic regions) separated for the most part by natural boundaries. The present study was designed to find the distribution of R. japonica in the Oriental region. Serologic surveys for antibodies to R. Japonica were conducted on Hainan Island in the southern part of China and also in Shandong Province of the eastern edge. Total of 499 serum specimens were collected from hospitals located in the northern, eastern, central, western, and southern parts of Hainan Island. Only one among 107 serum specimens collected in the southern part was found to contain antibodies reactive with R. Japonica at a high titer. Further survey also showed that one out of 331 serum specimens collected in the southern Hainan Island contained antibodies reactive with R. Japonica. The results indicated a possibility of the existence of a SFG rickettsiosis on the island, although its incidence seems to be very low. R. Japonica is likely to be a candidate for the causative agent, but the positive proof needs to isolate and identify the agent. Up to the present, the isolation of a SFG rickettsia has been performed without success. The present study also demonstrated a high incidence of murine typhus on Hainan Island. About 2.7 to 12% of serum specimens collected in the southern part reacted with R. Typhi, a half of which contained IgM antibodies, Furthermore, more than 60% of suspected rickettsial infections were murine typhus. In Shandong province, on the other hand, 1100 serum specimens were tested, demonstrating that 3 among 500 specimens from a hospital in Jinan city contained low titers of antibodies reactive with R. Japonica.

新近确定的斑点发烧组（SFG）立克人士的感染Japonica的感染主要在日本西南部被公认，面对太平洋。众所周知，各种SFG人力素物种出现在大部分与自然边界相隔的地理区域（生物地理区域）中。本研究旨在在东方区域找到Japonica R. japonica的分布。在中国南部的海南岛和东部边缘的山东省进行了针对荷兰河菌的抗体的血清学调查。总共从位于海南岛北部，东部，中部，西部和南部的医院收集了499个血清标本。在南部收集的107个血清标本中，只有一个在高滴度上包含与Japonica反应作用的抗体。进一步的调查还表明，在海南岛南部收集的331个血清标本中，有一个含有与J. Japonica反应作用的抗体。结果表明，岛上存在SFG立克菌病的可能性，尽管其发病率似乎很低。 Japonica可能是病因剂的候选者，但是积极的证据需要隔离和识别药物。直到当前，SFG人力车的隔离一直没有成功。本研究还表明，海南岛上的鼠Typhus发生率很高。在南部收集的血清标本中，约有2.7％至12％与Typhi反应，其中一半含有IgM抗体，此外，鼠Typhus中有超过60％的可疑人士感染。另一方面，在山东省，测试了1100个血清标本，表明来自吉南市一家医院的500个标本中有3个标本中，抗体含量低的抗体滴度低，与Japonica反应。