The effect of estrogen on blood pressure regulation during psychological stress and its mechanism

雌激素对心理应激时血压调节的作用及其机制

基本信息

  • 批准号:
    15590208
  • 负责人:
  • 金额:
    $ 2.3万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2004
  • 项目状态:
    已结题

项目摘要

We obtained the following results on the effect of estrogen on stress-induced pressor responses and its mechanism.(1)Estrogen attenuates pressor responses induced by psychological stresses through endothelial nitric oxide synthase(eNOS) overexpression in rats.Pressor response to the cage-switch stress tended to be suppressed in the female (F) group compared with the male (M) group in free moving rats using the telemetry system. Furthermore, these responses to the cage-switch and restraint stresses were attenuated significantly in the ovariectomized estrogen-treated (E) group compared with the placebo-treated (P) group. However, pretreatment of NOS inhibitor diminished the difference of the stress-induced pressor response between the P and E groups. Moreover, the expression of eNOS in the mesentery enhanced significantly in the E group compared with the M and P groups. These results suggest that estrogen attenuates psychological stress-induced pressor responses and the mesenteric eNOS overexpression could explain the mechanism for its effect in rats.(2)Pressor response to mental stress varies during menstrual cycle depending on plasma estradiol levels in women.The resting blood pressure(BP) was not different between the menstrual (M) and the pre-ovulatory (O) phases of menstrual cycle in young women(YW). The elevations of systolic BP(SBP) and diastolic BP(DBF) induced by the Color Word Test(CWT) were slightly, but not significantly attenuated in O-phase compared with M-phase. In addition, the resting plasma norepinephrine(NE) was higher in O-phase, and its CWT-induced elevation tended to be attenuated in O-phase. Furthermore, the resting DBF was higher in postmenopausal women(PM) than YW. The significant and immediate elevation of DBP during the CWT was greater in PM than in YW and continued until about 15 min of the recovery period. These findings suggest that estrogen may attenuate the DBP elevations induced by the mental stress in women.
本实验就雌激素对应激性升压反应的影响及其机制作了如下研究。(1)雌激素通过内皮型一氧化氮合酶(eNOS)的过度表达减弱心理应激引起的大鼠升压反应。此外,与安慰剂治疗组(P)相比,切除卵巢的雌激素治疗组(E)对笼子转换和束缚应激的反应显著减弱。而NOS抑制剂预处理可缩小P组和E组之间的差异。E组大鼠肠系膜eNOS表达较M组和P组明显增强。提示雌激素可减弱心理应激引起的升压反应,其机制可能与大鼠肠系膜eNOS过度表达有关。(2)女性在月经周期中对精神应激的升压反应随血浆雌二醇水平的变化而变化,青年女性(YW)在月经期(M)和排卵前(O)的静息血压(BP)无明显差异。与M期相比,色词试验(CWT)引起的收缩压(SBP)和舒张压(DBF)升高在O期略有减弱,但无显著性差异。此外,静息血浆去甲肾上腺素(NE)在O期较高,而CWT引起的NE升高在O期有减弱的趋势。此外,绝经后妇女(PM)的静息DBF高于YW。在CWT期间DBP的显著和立即升高在PM中比在YW中更大,并且持续到恢复期的约15分钟。这些结果表明,雌激素可能会减弱由精神应激引起的女性DBP升高。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Estrogen replacement suppresses stress-ind uceci caraiovascuiar responses in ovanectomized rats.
雌激素替代可抑制卵巢切除大鼠应激诱发的血管反应。
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Morimoto K;Kurahashi Y;Shintani-Ishida K;Kawamura N;Miyashita M;Uji M;Tan N;Yoshida
  • 通讯作者:
    Yoshida
Estrogen replacement suppresses stress-induced cardiovascular responses in ovariectomized rats
Estrogen replacement suppresses stress-induced cardiovascular
雌激素替代可抑制压力诱发的心血管疾病
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Morimoto K;Kurahashi Y;Shintani-Ishida K;Kawamura N;Miyashita M;Uji M;Tan N;Yoshida K.
  • 通讯作者:
    Yoshida K.
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MORIMOTO Keiko其他文献

MORIMOTO Keiko的其他文献

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{{ truncateString('MORIMOTO Keiko', 18)}}的其他基金

The suppressive effects of estrogen on stress-induced cardiovascular responses in female and complementary nutrients for postmenopausal women
雌激素对女性应激性心血管反应的抑制作用及绝经后女性的补充营养素
  • 批准号:
    23300275
  • 财政年份:
    2011
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Mechanisms of inhibitory effects of estrogens on psychological stress-induced pressor response via suppression of oxidative stress
雌激素通过氧化应激抑制心理应激引起的升压反应的机制
  • 批准号:
    20590230
  • 财政年份:
    2008
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Mechanisms responsible for the attenuating effects of estrogen on cardiovascular responses to psychological stress in the central nervous system and the peripheral vessels
雌激素减弱中枢神经系统和外周血管对心理应激的心血管反应作用的机制
  • 批准号:
    17590202
  • 财政年份:
    2005
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effect of estrogen on cardiovascular responses to psychological stress in rats
雌激素对大鼠心理应激心血管反应的影响
  • 批准号:
    13670064
  • 财政年份:
    2001
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A cross-adaptation in the cardiovascular and hormonal responses in rats to differene types of stress by physical training
体能训练对大鼠心血管和激素反应对不同类型压力的交叉适应
  • 批准号:
    05680090
  • 财政年份:
    1993
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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