The suppressive effects of estrogen on stress-induced cardiovascular responses in female and complementary nutrients for postmenopausal women

更年期或精神压力是心血管事件的危险因素。我们研究了雌激素抑制去卵巢(OVX)大鼠应激诱导的心血管反应的机制和绝经后妇女的补充营养素。在动物模型中，雌激素替代通过抑制OVX大鼠的肾素-血管紧张素系统来减弱笼子切换应激引起的升压反应。然而，葛根提取物对去卵巢大鼠的应激诱导的升压反应没有影响。在人体实验中，由颜色词测试引起的心理应激导致绝经后妇女与中年绝经前妇女相比，臂动脉血管阻力升高。此外，与绝经前妇女相比，绝经后妇女的基础内皮功能受损。然而，口服维生素C的预处理恢复了绝经后妇女的这些损害。

Menopause or mental stress is a risk factor for cardiovascular events. We examined the mechanisms accounting for suppressive effects of estrogen on stress-induced cardiovascular responses in ovariectomized (OVX) rats and complementary nutrients for postmenopausal women.In animal model, estrogen replacement attenuated pressor response to the cage-switch stress by suppressing the renin-angiotensin system in OVX rats. However, Kudzu root extracts had no effects on the stress-induced pressor responses in OVX rats.In human experiments, mental stress evoked by the Color Word Test induced the elevation in the vascular resistance of brachial artery in postmenopausal women compared with middle-aged premenopausal women. In addition, basal endothelial function was impaired in postmenopausal women compared with premenopausal women. However, the oral pretreatment of vitamin C restored these impairments in the postmenopausal women.