Effect of estrogen on cardiovascular responses to psychological stress in rats

雌激素对大鼠心理应激心血管反应的影响

基本信息

  • 批准号:
    13670064
  • 负责人:
  • 金额:
    $ 2.3万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2002
  • 项目状态:
    已结题

项目摘要

Estrogens are reported to have cardiovascular protective effects, but the mechanisms underlying these effects are not well defined. We investigated the sex difference in stress-induced cardiovascular responses and the effect of estrogen on these responses in free-moving adult rats. Furthermore, we assessed the central role of estrogen on the effect of corticotrophin-releasing hormone (CRH) in stress-induced cardiovascular responses.Four groups of rats, which consisted of male (M), normal female (NF), ovariectomized+placebo-treated (P) and ovariectomized+estrogen-treated (E) groups, were used in this experiment.1. Psychological stress was induced by cage-switch stress. After rats were placed in the novel environment, blood pressure and heart rate significantly increased. Blood pressure elevation was attenuated significantly in the NF group compared with the M group. Ovariectomy diminished the sex difference of blood pressure response to the stress.2. In the M group blood pressure elevat … More ion during cage-switch stress, which was repeated 60 min daily, was weakened on the 2nd and the 3rd days compared with the 1st day, but not in the NF group.2. The blood pressure responses were suppressed significantly in the E group compared with the P group during cage-switch and restraint stress. The plasma norepinephrine response induced by cage-switch stress was attenuated significantly in the E group.3. In unstressed NF, P and E group rats, the intracerebroventricular (I.C.V.) injection of CRF-41 (10 μg) increased blood pressure and heart rate. However, there were no significant differences between 3 groups.4. The I.C.V.injection of a-helical CRH (9-41), a CRH-41 receptor antagonist, did not attenuated the stress-induced hypertension in the 3 groups of female rats.These results suggest that estrogen may influence blood pressure regulation during stress in suppressing the activation of a sympathetic nervous tone in female rat. The mechanisms responsible for the greater resistance to these stresses in the NF and E group should be investigated further. Less
据报道,雌激素具有心血管保护作用,但这些作用的机制尚未明确。我们研究了自由活动的成年大鼠在应激诱导的心血管反应中的性别差异以及雌激素对这些反应的影响。本实验采用雄性大鼠(M组)、正常雌性大鼠(NF组)、去卵巢+安慰剂组(P组)和去卵巢+雌激素组(E组)四组大鼠,研究雌激素在促肾上腺皮质激素释放激素(CRH)干预应激性心血管反应中的作用.心理应激由转笼应激引起。将大鼠置于新环境后,血压和心率显著增加。与M组相比,NF组的血压升高明显减轻。结论:1.卵巢切除可缩小应激反应性血压的性别差异. M组血压升高, ...更多信息 每天重复60 min的换笼应激后,第2、3天大鼠海马CA 1+、CA 2+、CA 3+、CA 2+、与P组相比,E组大鼠在换笼应激和束缚应激时血压反应受到明显抑制。E组大鼠血浆去甲肾上腺素反应明显减弱. NF、P、E组大鼠侧脑室(I. C. V.)注射CRF-41(10 μg)增加血压和心率。但3组间差异无统计学意义.静脉注射CRH-41受体拮抗剂α-螺旋CRH(9-41)对3组雌性大鼠的应激性高血压均无明显抑制作用,提示雌激素可能通过抑制交感神经张力的激活而影响应激性血压的调节。NF和E组对这些应力具有更大抗性的机制应进一步研究。少

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Keiko Morimoto, Yoko Kurahashi, Nobusuke Tan: "Chronic estrogen replacement suppresses stress-induced cardiovascular responses in female rats"Circulation (Suppl). Vol 106, No 19. II-295 (2002)
Keiko Morimoto、Yoko Kurahashi、Nobusuke Tan:“慢性雌激素替代可抑制雌性大鼠应激诱发的心血管反应”Circulation(增刊)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Keiko Morimoto, Yoko Kurahashi, Nobusuke Tan: "Chronic estrogen replacement suppresses stress-induced cardiovascular responses in female rats"Circulation (Suppl). Vol 106-No 19. II-295 (2002)
Keiko Morimoto、Yoko Kurahashi、Nobusuke Tan:“慢性雌激素替代可抑制雌性大鼠应激诱发的心血管反应”Circulation(增刊)。
  • DOI:
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  • 期刊:
  • 影响因子:
    0
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MORIMOTO Keiko其他文献

MORIMOTO Keiko的其他文献

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{{ truncateString('MORIMOTO Keiko', 18)}}的其他基金

The suppressive effects of estrogen on stress-induced cardiovascular responses in female and complementary nutrients for postmenopausal women
雌激素对女性应激性心血管反应的抑制作用及绝经后女性的补充营养素
  • 批准号:
    23300275
  • 财政年份:
    2011
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Mechanisms of inhibitory effects of estrogens on psychological stress-induced pressor response via suppression of oxidative stress
雌激素通过氧化应激抑制心理应激引起的升压反应的机制
  • 批准号:
    20590230
  • 财政年份:
    2008
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Mechanisms responsible for the attenuating effects of estrogen on cardiovascular responses to psychological stress in the central nervous system and the peripheral vessels
雌激素减弱中枢神经系统和外周血管对心理应激的心血管反应作用的机制
  • 批准号:
    17590202
  • 财政年份:
    2005
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The effect of estrogen on blood pressure regulation during psychological stress and its mechanism
雌激素对心理应激时血压调节的作用及其机制
  • 批准号:
    15590208
  • 财政年份:
    2003
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A cross-adaptation in the cardiovascular and hormonal responses in rats to differene types of stress by physical training
体能训练对大鼠心血管和激素反应对不同类型压力的交叉适应
  • 批准号:
    05680090
  • 财政年份:
    1993
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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