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Objective assessment of exhausted conditions by using the parameters of pupil size and its variability

利用瞳孔大小参数及其变异性客观评估疲劳状况

基本信息

批准号：
15590563
负责人：
KOBAYASHI Fumio
金额：
$ 1.86万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590563/
关键词：
pupil size exhaustion sleepiness sleep restriction CCD camera 瞳孔疲労断眠

项目摘要

The relationships of parameters in pupil size and its variability with exhaustionwas examined. Changes of pupil size and its variation in darkness were recorded continuously for 660-720 seconds using infrared video cameras (IRIS C7364, Hamamatsu, and F2D, AMTech). Average pupillary diameter (PD), slow pupillary oscillations<1.0Hz (FFT amplitude), the pupillary fatigue ratio (PFR, average pupillary diameter/papillary diameter standard deviation), the pupillary unrest index (PUI, cumulative changes in pupil size based on mean values of consecutive data sequences) were calculated as parameters of pupillary activity. Fatigue, sleepiness, subjective symptoms of the subjects were assessed by Vital Exhaustion Scale, Subjective Tiredness Questionnaire, the Stanford Sleepiness Scale, Visual Analog Scale of Sleepiness, and CES-D. Heart rate variability, salivary Ig-A and cortisol, serum cortisol and DHEA-S were simultaneously assessed. Cross-sectional analysis was conducted in 17 hospital nurses (27.0 yrs) working on 3-shift system including night duty, and 38 male workers (43.4 yrs) visiting a clinic for their health check-ups. 13 healthy male students (.21.7 yrs) were examined in an. experimental conditions with 5-hour sleep restriction for 7 days.Results : In nurses, FFT amplitude correlated with fatigue (p<0.01) and sleepiness (p=0.05), and PFR correlated with sleepiness (p=0.04). PD was correlated with salivary and serum cortisol level (p<0.05). In workers, PUI was inversely correlated with depressive symptoms (p<0.05). PD was smaller, FFT amplitude was larger (p=0.03), and PFR was smaller (p=0.02) in sleep-restricted states in the students. Conclusions : Parameters calculated from pupil size correlated with symptoms of exhaustion

研究了瞳孔大小参数及其变化与疲劳的关系。使用红外摄像机（IRIS C7364、Hamamatsu 和 F2D、AMTech）连续记录瞳孔大小的变化及其在黑暗中的变化 660-720 秒。计算平均瞳孔直径（PD）、慢瞳孔振荡<1.0Hz（FFT幅度）、瞳孔疲劳比（PFR，平均瞳孔直径/乳头直径标准差）、瞳孔不安指数（PUI，基于连续数据序列平均值的瞳孔大小累积变化）作为瞳孔活动参数。采用生命力竭量表、主观疲劳问卷、斯坦福嗜睡量表、嗜睡视觉模拟量表和CES-D评估受试者的疲劳、嗜睡和主观症状。同时评估心率变异性、唾液 Ig-A 和皮质醇、血清皮质醇和 DHEA-S。对包括夜班在内的 17 名医院护士（27.0 岁）和 38 名到诊所进行健康检查的男性工作人员（43.4 岁）进行了横断面分析。 13 名健康男学生（0.21.7 岁）接受了检查。实验条件为限制 5 小时睡眠，持续 7 天。结果：在护士中，FFT 幅度与疲劳 (p<0.01) 和困倦 (p=0.05) 相关，PFR 与困倦相关 (p=0.04)。 PD与唾液和血清皮质醇水平相关(p<0.05)。在工人中，PUI 与抑郁症状呈负相关（p<0.05）。在睡眠受限状态下，学生的PD较小，FFT幅度较大（p=0.03），PFR较小（p=0.02）。结论：根据瞳孔大小计算出的参数与疲劳症状相关