Objective evaluation for drowsiness and exhausted conditions with indices of pupillary diameter and cardiovascular autonomic activities.

通过瞳孔直径和心血管自主活动指数客观评估困倦和疲惫状况。

• 批准号: 17590560
• 负责人: KOBAYASHI Fumio
• 金额: $ 2.3万
• 依托单位: Aichi Medical Univrsity
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590560/
• 关键词: papillary diameter; sleepiness; exhaustion; sleep latency; standard values; blink; 睡眠; 心拍; 抑うつ

We examined whether indices of papillary diameter are correlated with sleepiness or exhausted conditions.1) Among 48 out-patients with over-drowsiness (38 men and 10 women, mean age 46.0), the Pupillary Unrest Index (PUI) calculated based on the variation of papillary diameter significantly correlated (p<0.03) with the sleep latency measured by the Two Nap Sleep Test (TNST).2) No significant correlations were observed between cardiac autonomic functions and papillary indices.3) In the head -up tilting, no remarkable change was obtained either in the cardiac autonomic or papillary indices.4) We calculated a standard value for pupillary diameter among Japanese using the data of 143 healthy subjects. The diameter among fifties was 1.2mm (16%) smaller than that of the twenties.5) The PUT value was affected by the blink rate during measurement.From these findings, we concluded that the papillary indices might be an objective indicator of sleepiness or exhausted condition. There are however, some basic problems to be solved.

1)在48例过度嗜睡的门诊患者(男38例，女10例，平均年龄46.0岁)中，根据乳头直径的变化计算的瞳孔不宁指数(PUI)显著相关(p&lt；2)心脏自主神经功能与乳头指标无显著相关性。3)在仰卧位时，心脏自主神经和乳头指标均无明显变化。4)利用143名健康受试者的数据计算了日本人的瞳孔直径标准值。50岁之间的直径比20岁时小1.2 mm(16%)。5)PUT值受测量时眨眼频率的影响，提示乳头指数可能是反映困倦或疲惫状态的客观指标。然而，还有一些基本问题需要解决。

项目成果

眠気の客観的評価に関する瞳孔径計測の一考察

瞳孔直径测量客观评估睡意的考虑

• 发表时间: 2006
• 期刊: 平成18年度日本産業衛生学会東海地方会学会講演集
• 作者: 山本敬子;小林章雄
• 通讯作者: 小林章雄

Pupillary Unrest Index (PUI) as an objective indicator of over-drowsiness in daytime

瞳孔不安指数（PUI）作为白天过度困倦的客观指标

• 发表时间: 2006
• 期刊: Ninth International Congress of Behavioral Medicine Abstract
• 作者: Yamamoto K;Shiomi T;Ito A;Banno K;Sasanabe R;Akamatsu Y;Kobayashi F
• 通讯作者: Kobayashi F

Pupillary Unrest Index (PUI) as an objective indicator of over-drowsiness in daytime.

瞳孔不安指数（PUI）作为白天过度困倦的客观指标。

• 发表时间: 2006
• 期刊: Ninth International Congress of Behavioral Medicine, Abstract
• 作者: Yamamoto K;Shiomi T;Ito A;Banno K;Sasanabe R;Akamatsu Y;Kobayashi F.
• 通讯作者: Kobayashi F.

Change in pupil diameter relates to subjective drowsiness.

瞳孔直径的变化与主观睡意有关。

• 发表时间: 2005
• 期刊: The 26th Pupil Colloquium 2005, Abstract
• 作者: Yamamoto K;Hori R;Tsuboi T;Akamatsu Y;Kobayashi K.
• 通讯作者: Kobayashi K.

Five-Hour Sleep Restriction for 7 Days Increases Subjective Sleepiness

连续 7 天限制 5 小时睡眠会增加主观睡意

• 发表时间: 2007
• 期刊: Industrial Health 45
• 作者: Kobayashi F;Yamamoto K;Tsuboi H;Hori R;Watanabe M;Akamatsu Y;Tomita T
• 通讯作者: Tomita T