权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Facial recognition in patients with Williams syndrome-an MEG study-

威廉姆斯综合征患者的面部识别——一项 MEG 研究——

基本信息

批准号：
15591152
负责人：
NAKAMURA Miho
金额：
$ 2.24万
依托单位：
Institute for Developmental Research, Aichi Human Service Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591152/
关键词：
Williams syndrome magnetoencephalography MEG face Face inversion effect 視覚認知腹側経路 Williams症候群

项目摘要

We examined face perception processing in a patient with Williams syndrome(WMS) using magnetoencephalography(MEG) by evaluating responses to the upright and inverted face stimuli. The face-perception-specific MEG component, 2M, was clearly identified in response to both upright and inverted face images in this patient, but its peak latency to the inverted face was shorter than that to the upright face. This finding was much different from that in healthy subjects, who usually showed a longer latency of 2M for the inverted face than for the upright face, which is the "face inversion effect". In the present patient with WMS, the "face inversion effect" was absent, meaning the peak latency of the 2M for the inverted face stimuli was not prolonged than that for the face upright stimuli. The peak latency for the upright face was not different from that of the healthy subjects. In each stimulus session, the locations of the dipole sources of the 2M component were estimated in the inferior temporal lobe and posterior part of the occipital lobe, which were consistent with those obtained in healthy subjects.These findings indicate that neurophysiological process of upright face perception in this patient is not different from those of healthy subjects at least concerning the face-perception-specific MEG component 2M, whereas, that of the inverted faces was different from those in healthy subjects in terms of latency, indicating the absence of inversion effects. The phenomenon may indicate a predominance of local processing in the patient, since local processing is considered to be necessary in the processing of inverted faces.

我们用脑磁图（MEG）检查了一名威廉姆斯综合征（WMS）患者对直立和倒置面孔刺激的反应。面部知觉特异性MEG成分2M在该患者对直立和倒置面部图像的反应中被清楚地识别，但其对倒置面部的峰潜伏期短于对直立面部的峰潜伏期。这一发现与正常人的情况有很大的不同，正常人通常表现为倒置脸的潜伏期比直立脸的潜伏期长2M，这就是“脸倒置效应”。在本例WMS患者中，不存在“面部倒置效应”，这意味着倒置面部刺激的2M峰潜伏期并不比直立面部刺激的2M峰潜伏期延长。直立脸的峰潜伏期与健康受试者无差异。在每次刺激中，2M成分的偶极子源位于颞叶下叶和枕叶后部，与正常人一致，表明该患者直立面孔知觉的神经生理过程与正常人没有差异，至少在面孔知觉特异性MEG成分2M方面是如此。在潜伏期方面，倒置面孔的反应与健康受试者的反应不同，表明没有倒置效应。这种现象可能表明患者的局部处理占主导地位，因为局部处理被认为是处理倒置面部所必需的。