Study of the expressions of differenciation factors to olfactory neuron in the olfactory epithelium of human and the other animal.

人和动物嗅上皮嗅神经元分化因子表达的研究。

• 批准号: 15591801
• 负责人: MIWA Takaki
• 金额: $ 2.24万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591801/
• 关键词: olfactory mucosa; olfactory neuron; biopsy; tissue culture; 成長因子; 嗅上皮生検; 嗅覚障害; 栄養因子

The purpose of this research was to prove the expression of some factors related with differentiation to the mature olfactory neuron in human olfactory mucosa. The olfactory mucosa removed by a special forceps under the patient's agreement were divided three types, existing olfactory neural cells, existing only respiratory column cells and missing any epithelial cells by the mechanical artifacts. Some neural markers were observed-sparsely in the olfactory epithelium by immunohistochemical study. However, any markers related with neural differentiation were not found in the human olfactory epithelium and cultured tissue in this experiment system. It is seemed that more ingenuity is needed at the course of removal, fixation and tissue culture of olfactory epithelium.

本研究的目的是证实一些与成熟嗅神经元分化相关的因子在人嗅黏膜中的表达。在患者的同意下，用特殊的钳子取出的嗅黏膜分为三种类型，即存在嗅神经细胞、仅存在呼吸柱细胞和因机械假体而丢失任何上皮细胞。免疫组织化学显示嗅觉上皮内有少量神经标记物。然而，在本实验系统中，人嗅觉上皮和培养组织中没有发现任何与神经分化有关的标志物。在嗅上皮的去除、固定和组织培养过程中，似乎还需要更多的巧妙。

项目成果

今日の耳鼻咽喉科・頭頸部外科治療指針

今日耳鼻喉科/头颈外科治疗指南

• 发表时间: 2018
• 作者: Sawada O;Ichiyama Y;Obata S;Ito Y;Kakinoki M;Sawada T;Saishin Y;Ohji M;喜田照代;岩崎 聡
• 通讯作者: 岩崎 聡

嗅裂病変の処置

嗅裂病变的治疗

• 发表时间: 2003
• 期刊: ENTONI 22
• 作者: Miwa T;Furukawa M;Tsukatani T;Ikeno S;Yata T;Horikawa I;Deguchi Y;Saito S;三輪高喜他;三輪高喜他;三輪高喜
• 通讯作者: 三輪高喜

嗅覚障害の診断と治療

嗅觉障碍的诊断和治疗

• 发表时间: 2022
• 作者: Yamahara K;Yamamoto N;Kuwata F;Nakagawa T.;菊田 周
• 通讯作者: 菊田 周

嗅覚障害の治療

嗅觉障碍的治疗

• 发表时间: 2010
• 期刊: MB ENT 117
• 作者: 小林正佳

嗅覚障害の診断と治療 課題と今後の展望

嗅觉障碍的诊断和治疗：挑战和未来前景

• 发表时间: 2006
• 期刊: 耳鼻咽喉科・頭頸部外科 78・2
• 作者: Hitoshi Satoh;et al.;Hitoshi Satoh;Hitoshi Satoh;佐藤 斎;佐藤 斎;Hitoshi Satoh;佐藤 斎 他;Hitoshi Satoh;三輪高喜
• 通讯作者: 三輪高喜