Basic research for olfactory nerve transplantation in mice
Basic research for olfactory nerve transplantation in mice
批准号:
10671586
负责人:
MIWA Takaki
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2000
中文摘要
目的:探索嗅上皮移植治疗嗅觉障碍的新方法。研究设计:将供体小鼠的嗅粘膜挑取物插入受体小鼠的鼻腔中。各种条件组织用于供体(例如,成人或成熟的,完整或切片的粘膜,基底细胞提取物)。使小鼠存活7 - 28天。免疫组化分析移植组织使用抗蛋白基因产物9.5和嗅觉标记蛋白抗体。结果:受体鼻腔内无嗅神经元存活。可能是炎症反应或异物排斥反应抑制了移植组织的存活。
英文摘要
Objective: To develop a new treatment for olfactory disturbance transplantation of olfactory epithelium attempted to mice. Study design: Olfactory mucosa pick off donor mouse was inserted into nasal cavity of recipient mouse. Varied conditioned tissues were used for donor (ex, adult or in matured, whole or sliced mucosa, extract of basal cells). Recipient mouse was allowed to survive for 7 to 28days. An immunohistochemical analysis of transplanted tissue was done using both anti protein gene product 9.5 and olfactory marker protein antibody. Results: There were no survived olfactory neuron in recipient's nasal cavity. It is suspected that inflammation or rejection for foreign body inhibited the survive of transplanted tissue.
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Nishimura T, Miwa T, Furukawa M et al: "Glucocorticoid enhances Na/K ATPase mRNA expression in rat olfactory mucosa during regeneration"Chemical Senses. 27. 13-22 (2002)
Nishimura T、Miwa T、Furukawa M 等人:“糖皮质激素在再生过程中增强大鼠嗅粘膜中 Na/K ATP 酶 mRNA 的表达”Chemical Senses。
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三輪高喜他: "Impact of olfactory impairment quality of life and disability"Arch. Otolaryugol. Head Neck Surg.. 127. 497-503 (2001)
Takaki Miwa 等人:“嗅觉障碍对生活质量和残疾的影响”Arch. Otolaryugol. 127. 497-503 (2001)
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西村俊郎他: "Glucocorticoid enhances Na^+/K^+ATpase mRNA expression in rat olfactory mucosa during regeneration"Chemical Senses. 27. 13-22 (2002)
Toshiro Nishimura 等人:“糖皮质激素在再生过程中增强大鼠嗅粘膜中的 Na^+/K^+ATpase mRNA 表达”Chemical Senses。27. 13-22 (2002)
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三輪高喜他: "TrkA expression in mouse olfactory tract following anotomy of olfactory nerv"Acta Otolaryngol. Suppl. 539. 79-82 (1998)
Takaki Miwa 等:“嗅神经解剖后小鼠嗅道中的 TrkA 表达”Acta Otolaryngol. 539. 79-82 (1998)
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三輪高喜他: "The role of nerve growth factor in the olfactory system"Microscopy Research and Teckinigue. (印刷中). (2002)
Takaki Miwa 等人:“神经生长因子在嗅觉系统中的作用”显微镜研究和 Teckinigue(印刷中)。
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共 10 条
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Cerebral activities induced by odor stimulation using NIRS and MEG
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财政年份:2008
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Determination of human brain area activated following olfactory stimulation using near-infraied
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财政年份:2006
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Study of the expressions of differenciation factors to olfactory neuron in the olfactory epithelium of human and the other animal.
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财政年份:2003
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Study of the cyclic ADP-ribose signal system in the olfactory pathway
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负责人:MIWA Takaki
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依托单位:
海外基金