Implant placement in irradiated bone ?Effects of hydroxyapatite after anodic oxidation and hydrothermal treatment

种植体植入受辐射骨中？阳极氧化和水热处理后羟基磷灰石的影响

• 批准号: 15592061
• 负责人: ITOH Sozo
• 金额: $ 2.18万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592061/
• 关键词: Iimplant; Osseointegration; Maxillofacial prosthesis; Rradiation; Bone; Titanium; Aanodic oxidation; Hhydrothermal treatment; 顎顔面補綴

Purpose:Although there have been several reports concerning the use of osseointegrated implants for maxillofacial prosthesis, little is still understood about the effects of radiation on the bone/titanium interface. Since it is quite important to know this relationship when dealing with cases where implants have been inserted into the bone after radiotherapy. We reported that the primary stage of calification on the bone/titanium interface was affected upon the amount of radiation exposure. In this study, we use the pure Ti rods in vivo experiment and measured bonding strength to irradiated bone.Method:Tapered pure titanium rods that were 1-2 mm in diameter and 15 mm in length were employed. The surface of titanium was machine polished. Under general anesthesia, approximately 0.04Gy, 0.4Gy, 4Gy, 40Gy was irradiated to each one side femoral of Japanese white rabbits. After 24hours, three titanium rods were inserted into drilled holes press-fitted to a tapered shape in the each femoral. At 2 or 3weeks after insertion, the specimens were harvested, and a push-out test was performed at a crosshead speed of 0.5 mm/mm. Afterwards, the surfaces of the specimens were observed by a SEM and EDX (Energy Dispersive X-ray Fluores cence Spectrometer).Results:Irradiation doses under 4Gy induced no significant changes of the strength between the bone/titanium interfaces.The bone bonding strength were affected upon 40Gy radiation exposure after 3weeks implantation.CONCLUSIONThe bone bonding strength between the bone/titanium interfaces were affected upon the amount of radiation exposure.

目的：虽然已有一些关于骨整合种植体在颌面部假体中的应用的报道，但对辐射对骨/钛界面的影响仍知之甚少。因为在处理放疗后植入到骨中的植入物时，了解这种关系是非常重要的。我们报道了骨/钛界面钙化的初期阶段受照射剂量的影响。在体内实验中，我们使用纯钛棒材，测量其与照射骨的结合强度。方法：采用直径1~2 mm、长15 mm的锥形纯钛棒材。钛的表面经过了机械抛光。在全身麻醉下，对日本大白兔一侧股骨进行约0.04Gy0.4Gy4Gy40Gy四种剂量的照射。24小时后，将三根钛棒插入每个股骨压接成锥形的钻孔中。植入后2周或3周取材，以0.5 mm/mm的十字头速度进行顶出试验。结果：照射剂量低于4Gy时，骨/钛界面结合强度无明显变化，种植3周后，40Gy射线照射对骨结合强度有影响。结论骨/钛界面结合强度受照射剂量的影响。