Neuropathological research of argyrophilic grain dementia

嗜银性颗粒性痴呆的神经病理学研究

基本信息

批准号：
16500230
负责人：
YOSHIDA Mari
金额：
$ 1.79万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

Argyrophilic grain dementia (AGD) is a late onset tauopathy characterized by the occurrence of argyrophilic and tau-immunoreactive grains most abundant in the limbic system, especially in the CA1 region of the hippocampus, the entorhinal and transentorhinal cortex, the adjacent temporal isocortex, and the amygdala. These oval, spindle-shaped or comma-like grains can be best detected by the Gallyas-Braak silver technique. Many tau-immunoreactive pretangles with poor neurofibrillary tangles (NFT)-formation are distributed in the limbic system. Tau-immunoreactive glial changes seen in oligodendroglial coiled bodies and astrocytes represent a consistent finding. Ballooned neurons expressing a B-crystallin are constant features in the amygdala of AGD brains. NFT found in AGD patients generally correspond to early (transitional and limbic) Braak stages.The prevalence of AGD increases with advancing age. Frequency of AGD in 32 centenarians among 3328 autopsied brains was 31.3%. In the demented group, 9 (39.1%) of 23 Cases were found with AGD, while in the non-demented group, AGs were found on only 1 (11.1%) of nine cases. Dementia caused by pure AGD accounted for 13% (3/23) among demented subjects. Frequency of AGD in 110 cases with amyotrophic lateral sclerosis (age 32〜86) was 20%. Clinically 7 cases showed mild mental symptoms. Clinicopathological spectrum of AGD remains to be unclear.We reported a case with severe frontotemporal atrophy accompanied by numerous AGs. At the age of 49, he exhibited personality change, speech disorder and abnormal behavior. The neuropathological findings of extensive-type AGD would constitute a part of pathological background of frontotemporal dementia.AGs were immunopositive for 4-repeat tau on immunohistochemical study, using two monoclonal antibodies, RD3, RD4 that effectively distinguish between 3-repeat and 4-repeat tau.

弧菌谷物痴呆症（AGD）是一种晚期发作的呼吸病，其特征是在边缘系统中最丰富的芳族嗜血杆菌和tau-免疫反应性谷物，尤其是在河马的CA1区域，eNorthinal和enternalinal和sernentornalninal Cortex，Ambistect is actactacent和Amborla和Amborna。这些椭圆形，纺锤形或逗号状的晶粒最好通过Gallyas-Braak银技术来检测。许多tau免疫反应性甲状腺突袭，具有较差的神经原纤维缠结（NFT） - 形式分布在边缘系统中。在寡头盘绕的身体和星形胶质细胞中看到的tau免疫反应性神经胶质变化代表了一致的发现。表达B-晶状体蛋白的气球神经元是AGD大脑的杏仁核的恒定特征。在AGD患者中发现的NFT通常对应于早期（过渡和边缘）Braak阶段。AGD的患病率随着年龄的增长而增加。在3328个尸体式大脑中，32百岁时代的AGD频率为31.3％。在痴呆群中，发现了23例AGD中的9例（39.1％），而在非痴呆组中，在9例九例中仅发现AGS的1例（11.1％）。由纯AGD引起的痴呆症在痴呆受试者中占13％（3/23）。在110例肌萎缩性侧性硬化症（32-86岁）的病例中，AGD的频率为20％。临床上7例出现轻微的心理症状。 AGD的临床病理范围尚不清楚。我们报道了许多AGS完成的严重额颞萎缩症的病例。在49岁那年，他暴露了人格变化，言语障碍和异常行为。广泛型AGD的神经病理学发现将构成额颞痴呆的病理背景的一部分。在免疫组织化学研究中，使用两种单克隆抗体，RD3，RD3，RD3，RD4有效区分了3- repepeat和4- repeatepeat tau。

项目成果

期刊论文数量（55）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degneration and amyotrophic lateral sclerosis

TDP-43 是额颞叶变性和肌萎缩侧索硬化症中泛素阳性 tau 阴性包涵体的组成部分

DOI：
发表时间：
2006
期刊：
Biochemical and Biophysical Research Communications 351
影响因子：
0
作者：
Arai T;Hasegawa M;Akiyama H;Ikeda K;Nonaka T;Mori H;Mann D;Tsuchiya K;Yoshida M;Hashizume Y;Oda T
通讯作者：
Oda T

Argyrophilic grain disease presenting with frontotemporal dementia : A neuropsychological and pathological study of an autopsied case with presenile onset.

伴有额颞叶痴呆的嗜银颗粒病：对老年前期发病的尸检病例的神经心理学和病理学研究。