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Mechanisms of suckling behavior

哺乳行为的机制

基本信息

批准号：
17590157
负责人：
MORIIZUMI Tetsuji
金额：
$ 1.34万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590157/
关键词：
Suckling Cranial nerves Motor nervous system Sensory nervous system Nerve injury Suckling behavior Survival Nipple attachment time 舌下神経顔面神経哺乳量成長生存

项目摘要

Functional roles of the perioral anatomical structures involved in breastfeeding were examined in newborn rat pups in which the hypoglossal (XII) and facial (VII) nerves had been resected at the neonatal stage. The XII nerve controls tongue movement and is comprised of two functionally distinct branches : the medial branch related to protrusion of the tongue and the lateral branch related to its retraction. Newborn rat pups with bilateral resection of either of the XII nerve components (main trunk : XII-trunk ; medial branch : XII-med ; lateral branch : XII-lat) failed to suckle milk and did not survive. Unilateral XII nerve-resected neonates showed different milk-suckling capabilities, which thus resulted in differences in survival rate (XII-trunk : 38% ; XII-med : 24% ; XII-lat : 92%) and postnatal growth during the postnatal three weeks until P21. The results indicate a crucial role of the tongue, especially of protruding muscular elements innervated by the XII-med nerve, in breastf … More eeding.The present study was performed to determine the effects of VII and XII nerve injuries on the survival and growth of rats in which the unilateral or bilateral VII and XII nerve components had been resected at different developmental stages. In the suckling period, unilateral as well as bilateral injuries in the XII-trunk or XII-med nerve produced disturbed milk intake, lower survival rates and growth retardation in the nerve-injured rats. In the transition and mastication periods, only bilateral injury in the XII-trunk or XII-med nerve produced disturbed food intake followed by lower survival rates and growth retardation in those animals. The unilateral VII nerve injury at the early neonatal stage caused deteriorating effects on food intake resulting in lower survival rate and severe growth retardation in the nerve-injured rats. The results indicate that the survival and growth of XII and VII nerve-resected rats differ considerably depending on the nerves injured and the developmental ages of the animals at the time of nerve insult.Functional role of lingual nerve (LN) in breastfeeding was investigated in rat pups during the suckling period. Unilaterally LN-injured pups did not show suckling disturbance with absence of any shortening (P11 pups : 559 ±16 sec ; 105% of the control value) in nipple attachment time and the survival rate remained high (P11 : 100%). Bilaterally LN-injured pups showed suckling disturbance with marked shortening (P11 pups : 220 ± 54 sec ; 42% of the control value) in nipple attachment time and a low survival rate (P1 : 33% ; P11 : 41%). Bilaterally infraorbital nerve-injured or bilaterally bulbectomized pups did not show any nipple attachment at all and there were no survivors, confirming the crucial roles of upper lip sensation and olfaction in suckling. Based on these findings, we conclude that tongue sensation is very important, but not essential for suckling. Less

在新生儿阶段切除舌下神经（XII）和面神经（VII）的新生大鼠幼崽中，研究了参与母乳喂养的口周解剖结构的功能作用。第十二神经控制舌的运动，由两个功能不同的分支组成：内侧分支与舌前伸有关，外侧分支与舌后缩有关。双侧切除任何XII神经成分（主干：XII-trunk；内侧分支：XII-med；外侧分支：XII-lat）的新生大鼠幼崽不能哺乳，不能存活。单侧XII神经切除的新生儿表现出不同的哺乳能力，从而导致出生后3周至P21的存活率（XII-trunk: 38%; XII-med: 24%; XII-lat: 92%）和出生后生长的差异。研究结果表明，舌头在哺乳过程中起着至关重要的作用，尤其是由十二脉神经支配的突出肌肉成分。本研究旨在探讨在不同发育阶段切除单侧或双侧第七、十二神经成分的大鼠，第七、十二神经损伤对其存活和生长的影响。在哺乳期，神经损伤大鼠的单侧和双侧第十二干或第十二侧神经损伤会导致摄乳障碍、成活率降低和生长迟缓。在过渡期和咀嚼期，只有双侧第十二干或第十二神经损伤引起摄食障碍，随后出现成活率降低和生长迟缓。新生儿早期单侧VII神经损伤导致大鼠摄食功能恶化，成活率降低，生长发育严重迟缓。结果表明，十二、七神经切除大鼠的存活和生长情况因神经损伤程度及损伤时发育年龄的不同而有较大差异。研究了舌神经（LN）在哺乳期大鼠幼鼠哺乳中的功能作用。单侧lnn损伤的幼犬没有出现哺乳障碍，乳头附着时间没有缩短（P11: 559±16秒，为对照组的105%），存活率仍然很高（P11: 100%）。双侧ln损伤的幼犬出现哺乳障碍，乳头附着时间明显缩短（P11只：220±54秒，为对照组的42%），存活率低（P1: 33%, P11: 41%）。双侧眶下神经损伤或双侧球切除的幼崽完全没有乳头附着，没有幸存者，证实了上唇感觉和嗅觉在哺乳中的重要作用。基于这些发现，我们得出结论，舌头的感觉是非常重要的，但不是必不可少的哺乳。少