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Effect of an alpha-lb adrenoceptor antagonist on methamphetamine-induced neuronal toxicity

Effect of an alpha-lb adrenoceptor antagonist on methamphetamine-induced neuronal toxicity
α-1b肾上腺素受体拮抗剂对甲基苯丙胺诱导的神经元毒性的影响
批准号:
17590228
负责人:
NAKAKI Toshio
金额:
$2.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006

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中文摘要
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英文摘要
A nonselective alpha-1 adrenoceptor antagonist prazosin protected methamphetamine-induced neuronal toxicity, while a selective alpha-lb adrenoceptor antagonist failed to do so. We conclude that the neuro-protective effect of prazosin is some unidentified mechanisms other than the alpha-lb receptor blockade.
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会议论文
A correlation of METH neurotoxicity with severe hyperthermia in rat striatum
冰毒神经毒性与大鼠纹状体严重高热的相关性
DOI: --
发表时间: 2007
期刊: Journal of Pharmacological Sciences 103
影响因子: --
作者: [Onohara, N., Nishida, M., Inoue, R., Kobayashi, H., Sumimoto, H., Sato, Y., Mori, Y., Nagao, T., Kurose, H., Utsumi K]
通讯作者: Utsumi K
A study on CNS oxidative stress-resistant mouse
  • 批准号:
    21590291
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2009
  • 负责人:
    NAKAKI Toshio
  • 依托单位:
Rotenone-Induced Parkinsonism
  • 批准号:
    14570088
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.92万
  • 财政年份:
    2002
  • 负责人:
    NAKAKI Toshio
  • 依托单位:
Implications of nitrocathecholamines in Parkinson's disease
  • 批准号:
    12680760
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.3万
  • 财政年份:
    2000
  • 负责人:
    NAKAKI Toshio
  • 依托单位:
Research on a novel endogenous catecholamine, 6-nitronorepinephrine
  • 批准号:
    09680771
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.3万
  • 财政年份:
    1997
  • 负责人:
    NAKAKI Toshio
  • 依托单位:
海外基金