The role of EET in cardiovascular disease.

EET 在心血管疾病中的作用。

• 批准号: 17590747
• 负责人: NODE Koichi
• 金额: $ 1.79万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590747/
• 关键词: endothelial function; atherosclerosis; endothelial cell

We investigate the role of CYP2J2 and soluble epoxide hydrolase and EET in the cardiovascular system. In patients with type II diabetes mellitus, single nucleoetide polymorphism of soluble epoxide hydrolase is associated with progression of insulin sensitivity.Fish oil, eicosapentaic acid increased the mRNA level of CYP2J2 which synthesize EET by activation PI-3 kinase and AKT in vascular endothelial cell.This result suggests that EET production by intake of fish oil might be involved in the mechanism of vascular protective effect of eicosapentaic acid.Several drugs including angiotensin receptor blocker also increase the level of CYP2J2 and EET production. This result may add the new mechanism of angiotensin receptor blocker on vascular endothelial function.Further study of angiogenesis by EET will be needed for the treatment of severe atherosclerosis.We proposed the new disease criteria "Vascular failure". Vascular failure include both endothelial dysfunction and smooth muscle dysfunction.Depletion of EET may promote the endothelial failure and EET is one of candidate of drug for vascular failure.

我们研究了 CYP2J2 以及可溶性环氧化物水解酶和 EET 在心血管系统中的作用。在II型糖尿病患者中，可溶性环氧化物水解酶的单核苷酸多态性与胰岛素敏感性的进展相关。鱼油、二十碳五酸增加了CYP2J2的mRNA水平，CYP2J2通过激活血管内皮细胞中的PI-3激酶和AKT合成EET。这一结果表明，摄入鱼油可能参与了EET的产生。 二十碳五酸的血管保护作用机制。包括血管紧张素受体阻滞剂在内的几种药物也会增加 CYP2J2 和 EET 产生的水平。这一结果可能增加了血管紧张素受体阻滞剂对血管内皮功能影响的新机制。严重动脉粥样硬化的治疗需要进一步研究EET的血管生成。我们提出了新的疾病标准“血管衰竭”。血管衰竭包括内皮功能障碍和平滑肌功能障碍。EET的耗竭可能促进内皮功能衰竭，EET是治疗血管衰竭的候选药物之一。

项目成果

Therapeutic potential of monteplase in acute myocardial infarction. (Review)

孟替普酶在急性心肌梗塞中的治疗潜力。

• 发表时间: 2005
• 期刊: Am J Cardiovasc Drugs. 5(4)
• 作者: Inoue T;Nishiki R;Kageyama M;Node K
• 通讯作者: Node K

Long-term benefits of monteplase before coronary angioplasty in acute myocardial infarction.

急性心肌梗死冠状动脉成形术前使用孟替普酶的长期益处。

• 发表时间: 2005
• 期刊: Am J Cardiol. 95・4
• 作者: 井上晃男

Stent-induced neutrophil activation is associated with an oxidative burst in the inflammatory process, leading to neointimal thickening

• DOI: 10.1160/th05-08-0591
• 发表时间: 2006-01-01
• 期刊: THROMBOSIS AND HAEMOSTASIS
• 影响因子: 6.7
• 作者: Inoue, T;Kato, T;Node, K
• 通讯作者: Node, K

Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometory.

通过基质辅助激光解吸电离飞行时间质谱法对少量血清中的硫苷脂进行定量、定性和高通量分析。

• 发表时间: 2006
• 期刊: Anal Biochem. 362・1
• 作者: 平瀬徹明;野出孝一;Li G
• 通讯作者: Li G

Vascular failure : A new clinical entity for vascular disease. (Review)

血管衰竭：血管疾病的新临床实体。

• 发表时间: 2006
• 期刊: J Hypertens. 24(11)
• 作者: Inoue T;Node K.
• 通讯作者: Node K.