Control of immune reactions associated with transplantation by hepatocyte growth factor and edg-1 ligand

1)FTY 720治疗可降低外周血淋巴细胞数量2）HGF和FTY 720联合治疗可显著预防急性GVHD引起的肠道损伤，从而延长GVHD小鼠的存活时间。3）HGF和FTY 720联合治疗可显著预防急性GVHD引起的胸腺损伤，4）HGF和FTY 720的联合治疗显著降低急性GVHD小鼠肠中TNF-α和IFN-γ mRNA的表达。5）FTY治疗预防慢性GVHD。

1) FTY720 treatment reduced the numbers of peripheral blood lymphocytes2) Combination treatment with HGF and FTY720 significantly prevented intestinal damages caused by acute GVHD, thereby prolonged the survival of GVHD mice.3) Combination treatment with HGF and FTY720 significantly prevented thymic damages caused by acute GVHD, thereby prolonged the survival of GVHD mice.4) Combination treatment with HGF and FTY720 significantly reduced TNF-a and IFN-y mRNA expressions in the intestine of acute GVHD mice.5) FTY treatment prevented chronic GVHD.