Sentinel lymph node mapping using 99m Tc-labeled mannosyl-neoglycoalbumin and small semiconductor gamma camera for gastrointestinal cancers.

使用 99m Tc 标记的甘露糖基新糖白蛋白和小型半导体伽玛相机对胃肠癌进行前哨淋巴结定位。

• 批准号: 17591369
• 负责人: HAYASHI Hideki
• 金额: $ 2.18万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591369/
• 关键词: cancer; sentinel lymph node; semiconductor gamma camera; Mannose binding lectins; reticuloendothelial cells; 網内系細胞親和性トレーサ

Mannnosyl-neoglycoalbumin (NMA) is a small sized particle which has a capability to bind to mannose receptors on reticuloendotherial cells. Thus, it is expected to show rapid clearance from its injection sites and high retention within regional lymph nodes (LNs) if it is used as a tracer for sentinel lymph node (SLN) mapping. Semiconductor gamma camera (SGC) is small enough to use in an operating room and has higher spatial resolution specificity compared with conventional scintillation camera. A new technique to map SLNs for gastrointestinal cancers using a combination of 99mTc-labeled NMA and SGC was proposed and its usefulness was tested in a swine model.99mTc-labeled NMA was administered to both stomach and rectum of three specific pathogen free swines of three-month-old. Mean number of 3 LNs, even nodes adjacent to the injection site, were depicted within the regional LNs area of the organ. Clearance of the tracer from injection sites was two times faster, and retention in the LNs was four times higher as compared to 99m-labeled tin colloid, that were commonly used for SLN mapping of gastrointestinal cancers in our country, indicating an usefulness of the new tracer to avoid so-called "shine-through phenomenon".SGC was also refined with furnishing an optical camera and a capability to out put real-time fusion images of real and radioactive view, in order to facilitate to pinpoint radioactive nodes. SGC of this new version was also tested on surgical specimen of gastric cancer, and injection sites were precisely localized on the synthesized images, thus, indicating that this new SLN mapping technique is useful and ready for clinical use.

Mannnosyl-neoglycoalbumin（NMA）是一个小尺寸的粒子，具有与网状细胞上的甘露糖受体结合的能力。因此，如果将其作为哨兵淋巴结（SLN）映射的示踪剂，预计它将从其注射部位从其注射部位快速清除和在区域淋巴结（LNS）内的高保留率。半导体伽马摄像头（SGC）足够小，可以在手术室中使用，并且与常规闪烁相机相比，空间分辨率的特异性更高。提出了一种新技术，以99mtc标记的NMA和SGC的组合为胃肠道癌绘制SLN，并在猪模型中测试了其实用性。99MTC标记的NMA均针对三个三个月的三个特定病原体的胃的胃和直肠和直肠。在器官的区域LNS区域内描绘了3个LN的平均数量，甚至是注射位点附近的节点。 Clearance of the tracer from injection sites was two times faster, and retention in the LNs was four times higher as compared to 99m-labeled tin colloid, that were commonly used for SLN mapping of gastrointestinal cancers in our country, indicating an usefulness of the new tracer to avoid so-called "shine-through phenomenon".SGC was also refined with furnishing an optical camera and a capability to out put实际和放射性视图的实时融合图像，以便于查明放射性节点。该新版本的SGC还在胃癌的手术标本上进行了测试，并且注射位点精确地定位于合成图像上，因此表明这种新的SLN映射技术很有用，可以用于临床使用。

项目成果

センチネルナビゲーション手術

哨兵导航手术

• 发表时间: 2005
• 期刊: 癌治療の新たな試み 新編III
• 作者: 林 秀樹;落合武徳
• 通讯作者: 落合武徳

センチネルリンパ節理論の消化器癌への応用-センチネルリンパ節生検応用の拡大 (2)腹腔鏡下手術への応用

前哨淋巴结理论在消化道肿瘤中的应用——扩大前哨淋巴结活检的应用（二）在腹腔镜手术中的应用

• 发表时间: 2007
• 期刊: 臨牀消化器内科 22・8
• 作者: 林 秀樹;川平 洋;武藤頼彦;落合武徳
• 通讯作者: 落合武徳

Sentinel lymph node navigation surgery.

前哨淋巴结导航手术。

• 发表时间: 2005
• 期刊: Ganchiryo-no-aratana-kokorimi shinnpenn-3
• 作者: Hideki Hayashi;Takeuchi Ochiai
• 通讯作者: Takeuchi Ochiai

Laparoscopic sentinel lymph node mapping for gastric cancers

腹腔镜胃癌前哨淋巴结定位

• 发表时间: 2007
• 期刊: Clinical Gastroenterology 22(8)
• 作者: Hideki Hayashi;Hiroshi Kawahira;Yorihiko Mutoh;Takeuchi Ochiai
• 通讯作者: Takeuchi Ochiai

撮像装置及び撮像システム

成像装置及成像系统

• 发表时间: 2005