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Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis

Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis
建立旨在改善类风湿关节炎患者生活质量的定制药物疗法
批准号:
20790140
负责人:
HAYASHI Hideki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
We evaluated the association of possible factors with the cumulative value of C-reactive protein in Japanese patients with RA. Polymorphisms of the reduced folate carrier gene (RFC) G80A and of the gamma-glutamylhydrolase gene (GGH) C-401T were more closely associated (beta = 2.1194, P = 0.0017) than other polymorphisms, with the anti-inflammatory response to MTX. Plasma homocysteine levels in patients with the MTHFR 677TT genotype were significantly higher than in those with the 677CC genotype (p < 0.05). In addition, plasma homocysteine levels were increased along with the elevation of general inflammatory markers.
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会议论文
DOI: 10.2133/dmpk.dmpk-10-sc-036
发表时间: 2010-01-01
期刊: DRUG METABOLISM AND PHARMACOKINETICS
影响因子: 2.1
作者: [Hayashi, Hideki, Horino, Masato, Itoh, Kunihiko]
通讯作者: Itoh, Kunihiko
ホモシステインと疾患活動性~関節リウマチにおける検討~ハイライト集収載
同型半胱氨酸与疾病活动-类风湿性关节炎研究-亮点集锦
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [林秀樹, 藤巻千裕, 坪井声示, 松山耐至, 原田直人, 伊藤邦彦]
通讯作者: 伊藤邦彦
DOI: 10.1111/j.1365-2710.2009.01046.x
发表时间: 2009-06-01
期刊: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
影响因子: 2
作者: [Hayashi, H., Fujimaki, C., Itoh, K.]
通讯作者: Itoh, K.
関節リウマチ患者におけるテーラーメイド薬物療法の実現を目指した遺伝子多型解析研究
基因多态性分析研究旨在实现类风湿关节炎患者的个体化药物治疗
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [藤巻千裕, 林秀樹, 松山耐至, 坪井声示, 井上和幸, 伊藤邦彦]
通讯作者: 伊藤邦彦
10
    Development of gene therapy using self-destructive lentivirus vectors
    • 批准号:
      16K15319
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2016
    • 负责人:
      HAYASHI Hideki
    • 依托单位:
    Fundamental analyses of our near-infrared fluorescent liposome system as therapeutic agents against gastrointestinal malignancies
    • 批准号:
      24591933
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      HAYASHI Hideki
    • 依托单位:
    Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.
    • 批准号:
      24590555
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      HAYASHI Hideki
    • 依托单位:
    A potential treatment of glaucoma by glia-derived lipoproteins.
    • 批准号:
      22790254
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      HAYASHI Hideki
    • 依托单位:
    海外基金