Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis
Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis
批准号:
20790140
负责人:
HAYASHI Hideki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
We evaluated the association of possible factors with the cumulative value of C-reactive protein in Japanese patients with RA. Polymorphisms of the reduced folate carrier gene (RFC) G80A and of the gamma-glutamylhydrolase gene (GGH) C-401T were more closely associated (beta = 2.1194, P = 0.0017) than other polymorphisms, with the anti-inflammatory response to MTX. Plasma homocysteine levels in patients with the MTHFR 677TT genotype were significantly higher than in those with the 677CC genotype (p < 0.05). In addition, plasma homocysteine levels were increased along with the elevation of general inflammatory markers.
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DOI:
10.2133/dmpk.dmpk-10-sc-036
发表时间:
2010-01-01
期刊:
DRUG METABOLISM AND PHARMACOKINETICS
影响因子:
2.1
作者:
[Hayashi, Hideki, Horino, Masato, Itoh, Kunihiko]
通讯作者:
Itoh, Kunihiko
ホモシステインと疾患活動性~関節リウマチにおける検討~ハイライト集収載
同型半胱氨酸与疾病活动-类风湿性关节炎研究-亮点集锦
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[林秀樹, 藤巻千裕, 坪井声示, 松山耐至, 原田直人, 伊藤邦彦]
通讯作者:
伊藤邦彦
DOI:
10.1111/j.1365-2710.2009.01046.x
发表时间:
2009-06-01
期刊:
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
影响因子:
2
作者:
[Hayashi, H., Fujimaki, C., Itoh, K.]
通讯作者:
Itoh, K.
関節リウマチ患者におけるテーラーメイド薬物療法の実現を目指した遺伝子多型解析研究
基因多态性分析研究旨在实现类风湿关节炎患者的个体化药物治疗
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[藤巻千裕, 林秀樹, 松山耐至, 坪井声示, 井上和幸, 伊藤邦彦]
通讯作者:
伊藤邦彦
関節リウマチ患者における血球中メトトレキサート濃度測定
类风湿性关节炎患者血细胞中甲氨蝶呤浓度的测定
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[林秀樹, 藤巻千裕, 坪井声示, 松山耐至, 井上和幸, 伊藤邦彦]
通讯作者:
伊藤邦彦
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Development of gene therapy using self-destructive lentivirus vectors
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批准号:16K15319
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Fundamental analyses of our near-infrared fluorescent liposome system as therapeutic agents against gastrointestinal malignancies
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批准号:24591933
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Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.
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批准号:24590555
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2012
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A potential treatment of glaucoma by glia-derived lipoproteins.
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批准号:22790254
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:HAYASHI Hideki
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依托单位:
Development the efficacious pharmacotherapy based on PK/PD/PGx analyses in patients with rheumatoid arthritis
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批准号:22790164
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.25万
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财政年份:2010
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负责人:HAYASHI Hideki
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依托单位:
Development of a dual-imaging sentinel lymph node detection method with the use of fluorescent liposome system
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批准号:21591693
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:HAYASHI Hideki
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依托单位:
Development of the method of dopaminergic neuron induction from ES cells using Wnt signaling pathway
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批准号:20890282
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
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资助金额:$2.08万
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财政年份:2008
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负责人:HAYASHI Hideki
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依托单位:
Near infrared imaging of indocyanine green for sentinel lymph node navigation using nano-sized particle
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批准号:19591531
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:HAYASHI Hideki
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依托单位:
Sentinel lymph node mapping using 99m Tc-labeled mannosyl-neoglycoalbumin and small semiconductor gamma camera for gastrointestinal cancers.
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批准号:17591369
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:HAYASHI Hideki
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依托单位:
Cloning of molecules that activate caspase9 regardless of cytochrome c.
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批准号:14599009
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:HAYASHI Hideki
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依托单位:
Research of Estimation Methads of Revised System of National Accounts
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批准号:06630019
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.7万
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财政年份:1994
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负责人:HAYASHI Hideki
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依托单位:
Studies on autodestructive cytokine production by pancreatic beta-cells
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批准号:05670888
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1993
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负责人:HAYASHI Hideki
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依托单位:
DEVELOPMENTS IN UPPER AIRWAY MUCOSAL INFLUENZA VIRUS VACCINES
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批准号:03454270
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.71万
-
财政年份:1991
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负责人:HAYASHI Hideki
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依托单位:
海外基金