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A potential treatment of glaucoma by glia-derived lipoproteins.

A potential treatment of glaucoma by glia-derived lipoproteins.
神经胶质衍生的脂蛋白对青光眼的潜在治疗。
批准号:
22790254
负责人:
HAYASHI Hideki
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Glaucoma is the leading cause of blindness in Japan. Thus, the aims of this study are to analyze mechanisms of developing glaucoma and neuroprotection by glia-derived lipoproteins. Glaucoma induces degeneration of retinal ganglion cells(RGCs), so we determined whether lipoproteins were able to protect primary cultured RGCs from degeneration induced by glutamate. This study demonstrated that lipoproteins protected RGCs from apoptosis by preventing calcium overload.
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会议论文
Protection from neurodegeneration by apolipoprotein E-containing lipoproteins
含载脂蛋白 E 的脂蛋白可防止神经变性
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [HAYASHI, Hideki, Hayashi H.]
通讯作者: Hayashi H.
Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity
低密度脂蛋白受体相关蛋白1介导含载脂蛋白E脂蛋白对谷氨酸神经毒性的神经保护作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Vance, J. E., and Hayashi, H., 古屋敷智之, Hayashi H.]
通讯作者: Hayashi H.
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hayashi H., Vance J. E., 林秀樹]
通讯作者: 林秀樹
Oxford University Press, Lipids, lipid mediators and other signaling molecules. Neuroglia, 3rd Edition
牛津大学出版社,脂质、脂质介质和其他信号分子。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Hayashi H., Vance J. E., 林秀樹, Hayashi H]
通讯作者: Hayashi H
8
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