A potential treatment of glaucoma by glia-derived lipoproteins.
A potential treatment of glaucoma by glia-derived lipoproteins.
批准号:
22790254
负责人:
HAYASHI Hideki
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Glaucoma is the leading cause of blindness in Japan. Thus, the aims of this study are to analyze mechanisms of developing glaucoma and neuroprotection by glia-derived lipoproteins. Glaucoma induces degeneration of retinal ganglion cells(RGCs), so we determined whether lipoproteins were able to protect primary cultured RGCs from degeneration induced by glutamate. This study demonstrated that lipoproteins protected RGCs from apoptosis by preventing calcium overload.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Protection from neurodegeneration by apolipoprotein E-containing lipoproteins
含载脂蛋白 E 的脂蛋白可防止神经变性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[HAYASHI, Hideki, Hayashi H.]
通讯作者:
Hayashi H.
Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity
低密度脂蛋白受体相关蛋白1介导含载脂蛋白E脂蛋白对谷氨酸神经毒性的神经保护作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Vance, J. E., and Hayashi, H., 古屋敷智之, Hayashi H.]
通讯作者:
Hayashi H.
アポリポプロテインE含有リポプロテインのアポトーシスに対する神経細胞保護
神经元对含载脂蛋白 E 脂蛋白凋亡的保护作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Hayashi H., Vance J. E., 林秀樹]
通讯作者:
林秀樹
Oxford University Press, Lipids, lipid mediators and other signaling molecules. Neuroglia, 3rd Edition
牛津大学出版社,脂质、脂质介质和其他信号分子。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Hayashi H., Vance J. E., 林秀樹, Hayashi H]
通讯作者:
Hayashi H
Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins(Neuro2010)
含载脂蛋白E的脂蛋白保护神经元免于凋亡(Neuro2010)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Hayashi H., Vance J. E.]
通讯作者:
Vance J. E.
共 8 条
Development of gene therapy using self-destructive lentivirus vectors
-
批准号:16K15319
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2016
-
负责人:HAYASHI Hideki
-
依托单位:
Fundamental analyses of our near-infrared fluorescent liposome system as therapeutic agents against gastrointestinal malignancies
-
批准号:24591933
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:HAYASHI Hideki
-
依托单位:
Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.
-
批准号:24590555
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2012
-
负责人:HAYASHI Hideki
-
依托单位:
Development the efficacious pharmacotherapy based on PK/PD/PGx analyses in patients with rheumatoid arthritis
-
批准号:22790164
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.25万
-
财政年份:2010
-
负责人:HAYASHI Hideki
-
依托单位:
Development of a dual-imaging sentinel lymph node detection method with the use of fluorescent liposome system
-
批准号:21591693
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
-
负责人:HAYASHI Hideki
-
依托单位:
Development of the method of dopaminergic neuron induction from ES cells using Wnt signaling pathway
-
批准号:20890282
-
项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$2.08万
-
财政年份:2008
-
负责人:HAYASHI Hideki
-
依托单位:
Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis
-
批准号:20790140
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2008
-
负责人:HAYASHI Hideki
-
依托单位:
Near infrared imaging of indocyanine green for sentinel lymph node navigation using nano-sized particle
-
批准号:19591531
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:HAYASHI Hideki
-
依托单位:
Sentinel lymph node mapping using 99m Tc-labeled mannosyl-neoglycoalbumin and small semiconductor gamma camera for gastrointestinal cancers.
-
批准号:17591369
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2005
-
负责人:HAYASHI Hideki
-
依托单位:
Cloning of molecules that activate caspase9 regardless of cytochrome c.
-
批准号:14599009
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2002
-
负责人:HAYASHI Hideki
-
依托单位:
Research of Estimation Methads of Revised System of National Accounts
-
批准号:06630019
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$0.7万
-
财政年份:1994
-
负责人:HAYASHI Hideki
-
依托单位:
Studies on autodestructive cytokine production by pancreatic beta-cells
-
批准号:05670888
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1993
-
负责人:HAYASHI Hideki
-
依托单位:
DEVELOPMENTS IN UPPER AIRWAY MUCOSAL INFLUENZA VIRUS VACCINES
-
批准号:03454270
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.71万
-
财政年份:1991
-
负责人:HAYASHI Hideki
-
依托单位:
海外基金