Development of a novel air pollution monitoring strategy - combining passive sampling with toxicity testing

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Present approaches for monitoring risk of air pollutants are limited to grab sample analysis for specific pollutants using concentrations based on independent toxicological and/or epidemiological assessment of compounds. This approach does not allow for evaluation of mixtures or that a given compound may exert different toxic endpoints and is based on short sampling periods. This research aims to develop and evaluate a novel approach combining extraction of pollutants using time-integrated passive samplers and toxicological evaluation using rapid in-vitro and in-vivo assays. The outcomes provide inexpensive tools for sensitive assessment of pollutant effects and baseline data to derive intervention guidelines based on mixture toxicity.