Development of a novel air pollution monitoring strategy - combining passive sampling with toxicity testing

开发新型空气污染监测策略——被动采样与毒性测试相结合

• 批准号: LP0560619
• 负责人: Prof Jochen Mueller
• 金额: $ 21.17万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0560619
• 关键词: Development; novel; air; pollution; monitoring

Present approaches for monitoring risk of air pollutants are limited to grab sample analysis for specific pollutants using concentrations based on independent toxicological and/or epidemiological assessment of compounds. This approach does not allow for evaluation of mixtures or that a given compound may exert different toxic endpoints and is based on short sampling periods. This research aims to develop and evaluate a novel approach combining extraction of pollutants using time-integrated passive samplers and toxicological evaluation using rapid in-vitro and in-vivo assays. The outcomes provide inexpensive tools for sensitive assessment of pollutant effects and baseline data to derive intervention guidelines based on mixture toxicity.

目前监测空气污染物风险的方法仅限于对特定污染物进行取样分析，使用基于化合物的独立毒理学和/或流行病学评估的浓度。这种方法不允许对混合物进行评价，也不允许对某一化合物可能产生不同的毒性终点进行评价，而且这种方法所依据的取样时间很短。 本研究的目的是开发和评估一种新的方法相结合的污染物提取使用时间积分被动采样器和毒理学评价使用快速的体外和体内试验。 结果提供了廉价的工具，敏感的评估污染物的影响和基线数据，以获得干预准则的基础上混合物的毒性。