From First Breath: Lung Development, Infection, Repair and Aging

从第一次呼吸开始：肺部发育、感染、修复和衰老

• 批准号: 10678811
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.65万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10678811
• 关键词: Acceleration; Address; Age; Aging; Air Pollution; Antiviral Response; Area; Articulation; Asthma; Biology; Cell Communication; Cells; Cellular biology; Chronic Obstructive Pulmonary Disease; Collaborations; Data; Development; Disease; Disease susceptibility; Educational workshop; Emerging Technologies; Epigenetic Process; Epithelium; Fostering; Friends; Geographic Locations; Goals; Health; Immune; Immune response; Individual; Infection; Inflammation; Joints; Knowledge; Learning; Life; Life Cycle Stages; Lung; Lung diseases; Malignant neoplasm of lung; Metabolism; Methodology; Modeling; Morbidity - disease rate; Natural regeneration; Oral; Outcome; Participant; Persons; Pneumonia; Population; Predisposition; Process; Publications; Pulmonary Fibrosis; Pulmonary Hypertension; Research; Research Personnel; Risk Factors; Scientist; Speed; Stimulus; Time; Tobacco smoking behavior; Utah; Virus Diseases; Work; antenatal; biological adaptation to stress; career; cell stroma; clinical practice; design; ethnic diversity; field study; forging; gender diversity; improved; insight; lung development; lung health; meetings; mortality; novel; posters; programs; regenerative; repaired; response; social; symposium; synergism

ABSTRACT Support is requested for a Keystone Symposia conference entitled From First Breath: Lung Development, Infection, Repair and Aging, organized by Drs. Carla Kim, Benjamin Singer and Nan Tang. The conference will be held in Snowbird, Utah from April 23 - 26, 2023. Lung diseases represent leading causes of morbidity and mortality worldwide. Beginning with antenatal development, the lung undergoes changes throughout the life course because of aging, as well as in response to infection and other injurious stimuli. There exist knowledge gaps in how individual cell populations coordinate and respond to these changes in states of health and disease over time. Therefore, this conference was designed to address how specific cell populations contribute to the formation and regeneration of the lung over the life course, as well as to examine metabolism, epigenetics, stress responses, and cell-cell interactions as features that control lung biology and how control mechanisms change over stages of life. This program will also aim to understand how emerging technologies and models will elucidate fundamental mechanisms of lung health and disease, and finally, how to articulate how the host immune response to infection determines reparative and regenerative processes. As a result of this meeting, attendees will have a more comprehensive view of dynamic mechanisms that drive pulmonary biology as it relates to health and disease as well as the newest approaches with which to understand these concepts. Finally, this conference will be held with another Keystone Symposia Conference, “Inflammation in the Lung: Friend or Foe in Viral Infections?” This pairing will allow participants to bridge the gap between classical antiviral responses carried out by innate and adaptive immune cells, and the involvement of other lung cells such as epithelia and stroma cells, and to deepen the understanding on how these cells interact. Ultimately, this Symposium will impact the field of lung biology by bringing together interdisciplinary groups of scientists that will synergize to propel discovery of mechanisms underlying lung health and disease.

摘要 要求支持一个题为"从第一次呼吸：肺部发育“的基石专题讨论会， 感染，修复和老化，由卡拉金博士，本杰明辛格和唐南组织。会议将 将于2023年4月23日至26日在犹他州雪鸟举行。 肺部疾病是全球发病率和死亡率的主要原因。从产前开始 随着年龄的增长，肺在整个生命过程中由于衰老而发生变化， 感染和其他有害刺激。在单个细胞群如何 协调和应对这些健康和疾病状况随时间的变化。因此，本次会议 旨在解决特定的细胞群如何有助于肺的形成和再生 在生命过程中，以及检查代谢，表观遗传学，应激反应和细胞间相互作用 作为控制肺部生物学的特征，以及控制机制如何在生命的各个阶段发生变化。此程序将 还旨在了解新兴技术和模型将如何阐明肺的基本机制， 健康和疾病，最后，如何阐明宿主对感染的免疫反应如何决定 修复和再生过程。由于这次会议，与会者将有一个更全面的 驱动肺生物学的动态机制的观点，因为它与健康和疾病以及 最新的方法来理解这些概念。最后，本次会议将与另一个 Keystone研讨会会议，“肺部炎症：病毒感染的朋友还是敌人？”这一组合将 使参与者能够弥合先天性和适应性抗病毒反应之间的差距， 免疫细胞，以及其他肺细胞如上皮细胞和基质细胞的参与，并加深 了解这些细胞如何相互作用。最终，本次研讨会将影响肺生物学领域， 将跨学科的科学家群体聚集在一起，协同推动机制的发现 潜在的肺部健康和疾病。