MALDI-MSMS

质谱法是一种横断面技术，在化学、生物化学和分子生物学的研究和教学中起着关键作用。波茨坦大学化学研究所（IfC）和生物化学与生物学研究所（IBB）的代表已经联合起来，将迫切需要的替换和新获得的单个质谱仪器与跨研究所质谱分析中心的建立结合起来。我们的目标是加强协同效应，分享和扩大波茨坦大学的分析专业知识。此外，我们打算协调各种分析技术的使用，以提高总体能力并防止修复瓶颈。作为一揽子提案的一部分，我们申请了MALDI-MSMS仪器，其中样品应用于晶体基质（替代提案/申请人Joerg Fettke），以满足波茨坦大学新成立的天然产物基因组学中心显著增加的样本量以及IfC和IBB对质谱的需求增加。作为包装提案的一部分，还需要以下额外设备：1)用于分析小挥发性分子的GC-MSMS仪器（替代提案/申请人Heiko Möller）；2)用于溶解样品的LC-ESI-IMS-MSMS仪器（替换提案和扩展，包括先前缺失的离子迁移率谱仪/申请人Heiko Möller）和3)LC-ESI-Orbitrap-MSMS仪器（新提案/申请人Elke Dittmann）。来自两个研究所的众多研究小组将受益于仪器的更高性能和多功能性（包括IMS和超高分辨率）以及显著增加的样品容量，并将能够推进具有国际竞争力的研究项目。

Mass spectrometry is a cross-sectional technology that plays a key role in chemical, biochemical and molecular biological research and teaching. Representatives of the Institute of Chemistry (IfC) and the Institute of Biochemistry and Biology (IBB) of the University of Potsdam have joined forces and combined the urgently needed replacements and a new acquisition of individual mass spectrometry instruments with the establishment of a cross-institute MS analytics center. Our aim is to strengthen synergy effects and to share and expand analytical expertise at the University of Potsdam. Further, we intend to coordinate the use of various analytical techniques, to enhance the overall capacity and to prevent repair bottlenecks. As part of a package proposal, we apply for a MALDI-MSMS instrument into which samples are applied in crystalline matrix (replacement proposal/applicant Joerg Fettke) in order to meet the significantly increased sample volume in the newly established Centre for Natural Product Genomics at the University of Potsdam and the increased demand for mass spectrometry at the IfC and IBB. As part of the package proposal, the following additional equipment is also requested: 1) a GC-MSMS instrument for the analysis of small, volatile molecules (replacement proposal/applicant Heiko Möller); 2) an LC-ESI-IMS-MSMS instrument for dissolved samples (replacement proposal and expansion to include the previously missing ion mobility spectrometry/applicant Heiko Möller) and 3) an LC-ESI-Orbitrap-MSMS instrument (new proposal/applicant Elke Dittmann).Numerous groups from both institutes will benefit from higher performance and versatility of the instruments (including IMS and ultra-high resolution) as well as the significantly increased sample capacity and will be able to advance internationally competitive research projects.