LC-ESI-MSMS system

LC-ESI-MSMS系统

• 批准号: 467315902
• 金额: --
• 依托单位: Universität Potsdam
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2022
• 资助国家: 德国
• 起止时间: 2021-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/467315902?language=en
• 关键词: LC; ESI; MSMS; system

Mass spectrometry is a cross-sectional technology that plays a key role in chemical, biochemical and molecular biological research and teaching. Representatives of the Institute of Chemistry and the Institute of Biochemistry and Biology of the University of Potsdam have joined forces and combined the urgently needed replacements and a new acquisition of individual mass spectrometry instruments with the establishment of a cross-institute MS analytics center. Our aim is to strengthen synergy effects and to share and expand analytical expertise at the University of Potsdam. Further, we intend to coordinate the use of various analytical techniques, to enhance the overall capacity and to prevent repair bottlenecks. As part of a package proposal, we apply for an LC-ESI-Orbitrap-MSMS instrument in order to meet the significantly increased sample volume in the newly established Centre for Natural Product Genomics at the University of Potsdam and the increased demand for ultra-high resolution mass spectrometry at the Institute of Biochemistry and Biology and the Institute of Chemistry. As part of the package proposal, the following additional equipment is also requested: 1) a GC-MSMS instrument for the analysis of small, volatile molecules (replacement proposal); 2) an LC-ESI-IMS-MSMS instrument for dissolved samples (replacement proposal and expansion to include the previously missing ion mobility spectrometry) and 3) a MALDI-MSMS instrument into which samples are applied in crystalline matrix (replacement proposal).Numerous groups from both institutes will benefit from higher performance and versatility of the instruments (including IMS and ultra-high resolution) as well as the significantly increased sample capacity and will be able to advance internationally competitive research projects.

质谱学是一门横截面技术，在化学、生物化学和分子生物学的研究和教学中发挥着关键作用。波茨坦大学化学研究所和生物化学与生物研究所的代表联合起来，将迫切需要的替代品和新获得的单个质谱仪与建立一个跨研究所的MS分析中心结合起来。我们的目标是加强协同效应，并分享和扩大波茨坦大学的分析专业知识。此外，我们打算协调各种分析技术的使用，以提高整体能力并防止修复瓶颈。作为一揽子建议的一部分，我们申请LC-ESI-Orbitrap-MSMS仪器，以满足波茨坦大学新成立的天然产物基因组学中心显著增加的样本量，以及生物化学和生物研究所和化学研究所对超高分辨率质谱学日益增长的需求。作为一揽子建议的一部分，还要求增加以下设备：1)一台用于分析小分子、挥发性分子的GC-MSMS仪器(替换建议)；2)一台用于溶解样品的LC-ESI-IMS-MSMS仪器(替换建议和扩展，以包括以前缺失的离子迁移率光谱)；以及3)一台MALDI-MSMS仪器，其中的样本以晶体基质形式应用(替换建议)。来自两个研究所的多个小组将受益于仪器的更高性能和通用性(包括IMS和超高分辨率)以及样品容量的显著增加，并将能够推动具有国际竞争力的研究项目。