Mass Spectrometer(high-resolution LC-ESI-IMS-MSMS Spectrometer)

质谱仪（高分辨率LC-ESI-IMS-MSMS质谱仪）

• 批准号: 467392869
• 金额: --
• 依托单位: Universität Potsdam
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2022
• 资助国家: 德国
• 起止时间: 2021-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/467392869?language=en
• 关键词: Mass; Spectrometer; resolution; LC; ESI

Mass spectrometry is a cross-sectional technology that plays a key role in chemical, biochemical and molecular biological research and teaching. Representatives of the Institute of Chemistry and the Institute of Biochemistry and Biology of the University of Potsdam have joined forces and combined the urgently needed replacements and a new acquisition of individual mass spectrometry instruments with the establishment of a cross-institute MS analytics center. Our aim is to strengthen synergy effects and to share and expand analytical expertise at the University of Potsdam. Further, we intend to coordinate the use of various analytical techniques, to enhance the overall capacity and to prevent repair bottlenecks. With main use in the Institute of Chemistry, here, we apply for an LC-ESI-IMS-MSMS instrument for the analysis of dissolved samples, on the one hand to replace the old ESI-MSMS spectrometer, which is prone to repair, and on the other hand to provide ion mobility spectrometry as a new, orthogonal method. The instrument will be used to perform high-resolution ESI measurements on small, polar molecules but also on peptides, proteins and their complexes. As part of the package proposal, the following additional equipment is also requested:1) a GC-EI-MSMS instrument for small, easily vaporizable analytes (replacement proposal / Institute of Chemistry), 2) a MALDI-MSMS instrument into which samples are applied in crystalline matrix (replacement proposal / Institute of Biochemistry and Biology), and 3) an ultra-high resolution LC-ESI-Orbitrap-MSMS instrument for dissolved samples (new acquisition proposal / Institute of Biochemistry and Biology).Numerous groups from both institutes will benefit from higher performance and versatility of the instruments (including IMS and ultra-high resolution) as well as the significantly increased sample capacity and will be able to advance internationally competitive research projects.

质谱法是一种横断面技术，在化学、生物化学和分子生物学的研究和教学中起着关键作用。波茨坦大学化学研究所和生物化学与生物学研究所的代表已经联合起来，将迫切需要的替换和新获得的单个质谱仪器与跨研究所质谱分析中心的建立结合起来。我们的目标是加强协同效应，分享和扩大波茨坦大学的分析专业知识。此外，我们打算协调各种分析技术的使用，以提高总体能力并防止修复瓶颈。本项目主要用于化学研究所，申请LC-ESI-IMS-MSMS仪器用于溶解样品的分析，一方面是为了取代易维修的旧ESI-MSMS光谱仪，另一方面是为了提供离子迁移率光谱法作为一种新的正交方法。该仪器将用于对小极性分子进行高分辨率ESI测量，也可用于多肽、蛋白质及其复合物。作为包装提案的一部分，还需要以下额外的设备：1)用于小型，易于蒸发的分析物的gc - i - msms仪器（替代提案/化学研究所），2)用于晶体基质样品的MALDI-MSMS仪器（替代提案/生物化学和生物学研究所），以及3)用于溶解样品的超高分辨率LC-ESI-Orbitrap-MSMS仪器（新收购提案/生物化学和生物学研究所）。来自两个研究所的众多研究小组将受益于仪器的更高性能和多功能性（包括IMS和超高分辨率）以及显著增加的样品容量，并将能够推进具有国际竞争力的研究项目。