Analysis on the relationship between longevity-associated mitochondrial DNA polymorphism, HLA type, lifestyle, and health condition

长寿线粒体DNA多态性与HLA型、生活方式及健康状况的关系分析

• 批准号: 14570355
• 负责人: KOKAZE Akatsuki
• 金额: $ 2.37万
• 依托单位: Kyorin Unviersity
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570355/
• 关键词: Longevity; Mitochondrial DNA; Polymorphism; Personalized Prevention; ミトコンドリア遺伝子; 飲酒習慣; 喫煙習慣; 肥満; 生活習慣; HLA; 健康状態

Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism is reportedly associated with longevity in Japanese. The frequency of the Mt5178A genotype is significantly higher in Japanese centenarians than in the general population and it is reported that individuals with Mt5178A are less susceptible to adult-onset diseases, such as type 2 diabetes, myocardial infarction and cerebrovascular disorders, except malignancy, than those with Mt5178C. Mt5178A genotype may exert antiatherogenic effect. We reported that Mt5178 C/A polymorphism is also associated with blood pressure, serum lipid levels, fasting plasma glucose levels and glucose tolerance, serum uric acid levels, intraocular pressure, hematological parameters, serum protein fraction levels, and serum electrolyte levels. Interactions between Mt5178 C/A polymorphism and habitual drinking on blood pressure, serum triglyceride levels, fasting plasma glucose levels and glucose tolerance, serum uric acid levels and intraocular pressure were reported. Interactions between Mt5178 C/A polymorphism and habitual smoking serum triglyceride levels, serum total cholesterol levels, serum low-density lipoprotein cholesterol levels, red blood cell counts, intraocular pressure and serum protein fraction levels were also reported. Some of these interactions may vary with body mass index. Individual modification of drinking and/or smoking habits based on Mt5178 C/A genotype may improve health conditions, such as blood pressure, serum lipid levels fasting glucose levels and glucose tolerance, and serum uric acid levels. Further investigation into the association between Mt5178 C/A polymorphism and health status may contribute to the establishment of personalized prevention strategies for lifestyle-related diseases.

线粒体DNA 5178胞嘧啶/腺嘌呤（Mt5178 C/A）多态性与日本人长寿相关。Mt5178 A基因型在日本百岁老人中的频率显著高于一般人群，据报道，Mt5178 A基因型的个体比Mt5178 C基因型的个体更不易患成人发病性疾病，如2型糖尿病、心肌梗死和脑血管疾病（恶性肿瘤除外）。Mt5178 A基因型可能具有抗动脉粥样硬化作用。Mt5178 C/A多态性还与血压、血脂水平、空腹血糖水平和糖耐量、血尿酸水平、眼内压、血液学参数、血清蛋白组分水平和血清电解质水平相关。报告了Mt5178 C/A多态性与习惯性饮酒对血压、血清甘油三酯水平、空腹血糖水平和糖耐量、血清尿酸水平和眼内压的交互作用。Mt5178 C/A多态性与习惯性吸烟的血清甘油三酯水平、血清总胆固醇水平、血清低密度脂蛋白胆固醇水平、红细胞计数、眼压和血清蛋白组分水平之间的相互作用也被报道。这些相互作用中的一些可能随体重指数而变化。基于Mt5178 C/A基因型的饮酒和/或吸烟习惯的个体改变可以改善健康状况，如血压、血脂水平、空腹血糖水平和葡萄糖耐量以及血清尿酸水平。进一步研究Mt5178 C/A多态性与健康状况的关系可能有助于建立生活方式相关疾病的个性化预防策略。

项目成果

Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men

• DOI: 10.1016/j.mad.2005.01.005
• 发表时间: 2005-06-01
• 期刊: MECHANISMS OF AGEING AND DEVELOPMENT
• 影响因子: 5.3
• 作者: Kokaze, A;Ishikawa, M;Takashima, Y
• 通讯作者: Takashima, Y

Akatsuki Kokaze et al.: "Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men"Experimental Gerontology. 38・10. 1071-1076 (2003)

Akatsuki Kokaze 等人：“长寿相关线粒体 DNA 5178 A/C 多态性调节日常饮酒和吸烟对日本中年男性血清甘油三酯水平的影响”实验老年学 38・1076。

Akatsuki Kokaze et al.: "Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population"Journal of Human Hypertension. 18・1. 41-45 (2004)

Akatsuki Kokaze 等人：“日本人群的长寿相关线粒体 DNA 5178 A/C 多态性和血压”《人类高血压杂志》18・1（2004 年）。

Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population

• DOI: 10.1038/sj.jhh.1001632
• 发表时间: 2004
• 期刊: Journal of Human Hypertension
• 影响因子: 2.7
• 作者: A. Kokaze;M. Ishikawa;N. Matsunaga;M. Yoshida;Y. Sekine;K. Sekiguchi;M. Harada;M. Satoh;K. Teruya;N. Takeda;S. Fukazawa;Y. Uchida;Y. Takashima

Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men

• DOI: 10.1111/j.1442-9071.2004.00796.x
• 发表时间: 2004-04-01
• 期刊: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• 影响因子: 4
• 作者: Kokaze, A;Yoshida, M;Takashima, Y
• 通讯作者: Takashima, Y