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Estrogen regulation of dopaminergoc nervous system in rats: morphological foundation for the hyportesis of puerperal psychosis

雌激素对大鼠多巴胺神经系统的调节：产后精神病低血压的形态学基础

基本信息

批准号：
14570918
负责人：
SHIROYAMA Takashi
金额：
$ 1.34万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570918/
关键词：
Estrogen Dopamine Interleukin-2 puerperal Psychosis

项目摘要

Recent studies have reported that estrogen regulates the activity of dopaminergic neurons (DA neurons) and may affect mood, cognition, and psychosis. Some authors have hypothesized of puerperal psychosis that serum estrogen level may play a role for psychotic symptoms. Changes in immune activation markers during puerperal period such as increased soluble interleukin-2 receptor levels have been also reported. Interleukin-2 (IL-2), which has been shown to modulate DA neurons as well, may be related to cognitive dysfunction and schizophrenia. Thus, changes in serum estrogen level and immune system, both of which affect DA neurons, may be involved in psychotic symptoms during puerperal period. However, it remains unclear how estrogen and IL-2 interact on modulating DA neurons. In the present study, distribution of interleukin-2 receptor α subunit (IL-2Rα) and estrogen receptor β (ERβ) in the rat central DA neurons were investigated using triple immunohistochemistry and confocal microscope. Present results showed colocalization of IL-2Rα and ERβ immunoreactivity in DA neurons in the ventral tegmental area, sustantia nigra pars compacta, and arcuate nucleus. This suggests that IL-2 and estrogen interact on regulating the activity of DA neurons mediated by IL-2 receptor and ERβ. Present study suggests the neuro-immuno-endcrinological modulation in the ventral tegmental area, substantia nigra pars compacta, and arcuate nucleus and provides the morphological foundation for the etiological hypothesis of puerperal psychosis.

最近的研究报道，雌激素调节多巴胺能神经元（DA神经元）的活性，并可能影响情绪，认知和精神病。有些作者提出了产褥期精神病的假说，认为血清雌激素水平可能对精神病性症状起作用。还报告了产褥期免疫活化标志物的变化，如可溶性白细胞介素-2受体水平升高。白细胞介素-2（IL-2）也可调节DA神经元，可能与认知功能障碍和精神分裂症有关。因此，血清雌激素水平和免疫系统的变化，这两个影响DA神经元，可能参与产褥期精神病症状。然而，雌激素和IL-2如何相互作用调节DA神经元仍不清楚。本研究应用免疫组织化学和共聚焦显微镜技术，观察了白细胞介素2受体α亚单位（IL-2 R α）和雌激素受体β（ERβ）在大鼠中枢DA神经元的分布。结果表明，IL-2 R α和ERβ免疫反应共定位于中脑腹侧被盖区、黑质腹侧部和弓状核的DA能神经元。提示IL-2和雌激素通过IL-2受体和ERβ介导对DA能神经元活动的调节而相互作用。本研究提示腹侧被盖区、黑质腹侧部和弓状核存在神经免疫内分泌调节，为产褥期精神病的病因假说提供了形态学依据。