Fundamental Research on the Development of a New Technology of Direct Hemoperfusion Aiming to Remove Immunosuppressive Cytokines from the Blood of Cancer-Bearing Hosts
Fundamental Research on the Development of a New Technology of Direct Hemoperfusion Aiming to Remove Immunosuppressive Cytokines from the Blood of Cancer-Bearing Hosts
批准号:
14571152
负责人:
UEDA Yuji
金额:
$1.92万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003
中文摘要
我们已经做了一个基础研究的发展,直接血液灌流,旨在消除免疫抑制细胞因子从血液中的癌症宿主。通过对聚苯乙烯基复合纤维进行化学改性,制备了免疫抑制物质吸附(伊萨)纤维。在多聚甲醛存在下,在硫酸和硝基苯的混合物中,用N-羟甲基-α-氯乙酰胺处理复合纤维。通过填充0.4g伊萨纤维制备容量为2 ml的无菌圆柱形塑料柱。通过将KDH-8细胞(肝细胞癌)皮下植入WKAH/Hm大鼠的背部制成荷瘤大鼠。使用这些柱对荷瘤大鼠进行直接血液灌流显著降低了肿瘤的生长。延长了他们的生存时间。这些柱有效地从荷瘤大鼠的血液中去除TGFb、VEGF和IL-6。
英文摘要
We have done a fundamental research on the development of a new technology of direct hemoperfusion aiming to remove immunosuppressive cytokines from the blood of cancer-bearing hosts. Immunosuppressive substance adsorption (ISA) fiber was prepared by chemical modification of a polystyrene-based composite fiber. In brief, the composite fiber is treated with N-methylol-α-chloroacetamide in a mixture of sulfuric acid and nitrobenzene in the presence of paraformaldehyde. Sterile cylindrical plastic columns with a capacity of 2 ml were prepared by filling 0.4 g of ISA fiber. Tumor-bearing rats were made by implanting KDH-8 cells (hepatocelllar carcinoma) subcutaneously into the back of WKAH/Hm rats. Direct hemoperfusion of tumor-bearing rats using these columns significantly reduced the tumor growth and. prolonged the survival of them. These columns efficiently removed TGFb, VEGF, and IL-6 from the blood of tumor-bearing rats.
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上田祐二, 他: "新しい癌の体外循環治療技術の開発"医学のあゆみ. 208・12. 1012-1013 (2004)
Yuji Ueda等人:“癌症体外循环治疗新技术的开发”医学史208・1013(2004年)。
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通讯作者:
Yuji Ueda, Yoshiki Yamamoto, Hisakazu Yamagishi, Masaaki Shimagaki, Kazuo Teramoto: "New Technology of Direct Hemoperfusion for Cancer Therapy"Igaku-no-Ayumi (in Japanese). 208(12). 1012-1013 (2004)
Yuji Ueda、Yoshiki Yamamoto、Hisakazu Yamagishi、Masaaki Shimagaki、Kazuo Teramoto:“癌症治疗直接血液灌流新技术”Igaku-no-Ayumi(日语)。
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Yuji Ueda, et al.: "Dendritic cell-based immunotherapy of cancer with the carcinoembryonic antigen-derived, HLA-A24-restricted CTL epitope."International Journal of Oncology. 24・4. 909-918 (2004)
Yuji Ueda 等人:“使用癌胚抗原衍生的 HLA-A24 限制性 CTL 表位进行基于树突状细胞的癌症免疫疗法”。《国际肿瘤学杂志》24·4(2004 年)。
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Yuji Ueda, et al.: "Dendritic cell based immunotherapy of cancer with the carcinoembryonic antigen-derived, HLPvA24-restricted CTL epitope."International Journal of Oncology. 24. 909-918 (2004)
Yuji Ueda 等人:“使用癌胚抗原衍生的 HLPvA24 限制性 CTL 表位进行基于树突状细胞的癌症免疫疗法。”国际肿瘤学杂志。
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上田祐二, 他: "新しい癌の体外循環治療技術の開発"医学のあゆみ. 208. 1012-1013 (2004)
Yuji Ueda 等人:“新型体外循环癌症治疗技术的开发”,医学史 208. 1012-1013 (2004)。
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