Development of treatment device for hepatic cancer using the heating mechanism of ferrite by an AC magnetic field

利用交流磁场的铁氧体加热机制开发肝癌治疗装置

• 批准号: 14571203
• 负责人: WATANABE Yuji
• 金额: $ 2.24万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571203/
• 关键词: AC magnetic field; ferrite; monoclonal antibody; liposome; hyperthemia; Ablation; 誘導加熱; フェライト; 磁性体; マグネタイト; 抗腫瘍モノクロナール抗体

As the basis for local hyperthermia, we employed various MFe2O4-type ferrite powders and compared their temperature increases upon application of an external AC magnetic field. At first, the AC magnetic fields, was investigated resulting ca,400kHz seemed most effective in heating. Then, heating materials were investigated. Four kinds of ferrite powder were investigated. All of the samples had the same mass(4g) except for chicken liver. The temperature increased for Mg-ferrite was the largest(+40℃ for 12min applictio of an AC agnetic field). Mn-ferrite and NB44 showd similar patterns of behavior. Their temperature increased by half in comparison with Mg-ferrite. Magnetite was the poorest among the four samples. These results suggest that Mg-ferrite powedre is appropriate for achieving local hyperethermia. At last, we miniaturized the materials to nanometer in diameter to apply in the blood vessels. In addition, ferrite poweder embedded in liposome was developed to bind monoclonal antibody againt human cancer cell surface antigen. This is expected to be a targetting local hyperthermia by AC magnetic field which may lead to minimally invasive cancer therapy by tumor heat-ablation.

作为局部热疗的基础，我们采用了不同的mfe2o4型铁氧体粉末，比较了它们在外加交流磁场作用下的温度升高。首先，对交流磁场进行了研究，结果表明，大约400kHz的磁场对加热最有效。然后对加热材料进行了研究。对四种铁氧体粉末进行了研究。除鸡肝外，所有样品的质量均为4g。mg -铁氧体的升温幅度最大（在交流磁场作用12min时升温+40℃）。mn -铁素体和NB44表现出相似的行为模式。与镁铁氧体相比，它们的温度升高了一半。磁铁矿是四个样品中最贫的。这些结果表明，镁铁氧体粉末是实现局部高热的合适材料。最后，我们将材料缩小到纳米直径，应用于血管。此外，还制备了包埋在脂质体中的铁氧体粉末，用于结合抗人癌细胞表面抗原的单克隆抗体。这有望成为一种利用交流磁场进行局部热疗的方法，从而实现肿瘤热消融的微创治疗。

项目成果

K.Konishi, T.Maehara, T.Kamimori, H.Aono, T.Naohara, H.Kikkawa, Y.Watanabe, K.Kawachi: "Heating ferrite powder with AC magnetic field for themal coagulation therapy"ICM2003(International Conference on Magnetism) in Rom, Italy. July 27-August 1. 5W-pm-17 7

K.Konishi、T.Maehara、T.Kamimori、H.Aono、T.Naohara、H.Kikkawa、Y.Watanabe、K.Kawachi：“用交流磁场加热铁氧体粉末进行热凝固治疗”ICM2003（国际会议）

C.Matuoka, T.Ishida, T.Maehara, K.Konishi: "Numerical study of temperature distribution in tissue for thermal coagulation therapy"ICM2003 (International Conference on Magnetism) in Rome, Italy, Abstract book. 748-748 (2003)

C.Matuoka、T.Ishida、T.Maehara、K.Konishi：“热凝固治疗组织中温度分布的数值研究”ICM2003（国际磁学会议），意大利罗马，摘要书。

C.Matsuoka, T.Ishida, T.Maehara, K.Konishi: "Numerical study of temperature distribution in tissue for thermal coagulation therapy."ICM2003(International Conference on Magnetism) in Rom, Italy. July 27-August 1. 5W-pm-16 748 (2003)

C.Matsuoka、T.Ishida、T.Maehara、K.Konishi：“热凝固治疗组织中温度分布的数值研究”。ICM2003（国际磁学会议），意大利罗马。

T.Maehara, K.Konishi, T.Kamimori, H.Aono, T.Naohara, H.Kikkawa, Y.Watanabe, K.Kawachi: "Heating of Ferrite Powder by an AC Magnetic Field for Local Hyperthermia"Jpn.J.Appl.Phys.. 41. 1620-1621 (2002)

T.Maehara、K.Konishi、T.Kamimori、H.Aono、T.Naohara、H.Kikkawa、Y.Watanabe、K.Kawachi：“通过交流磁场加热铁氧体粉末以实现局部热疗”Jpn.J。

T Maehara, Y Watanabe, T Naohara: "Heating of Ferrite Powder by an AC magnetic field for local hyperthermia"Japanese Journal of Applied Physics. 41. 1620 (2002)

T Maehara、Y Watanabe、T Naohara：“通过交流磁场加热铁氧体粉末以实现局部热疗”日本应用物理学杂志。