Development of a novel minimally invasive treatment of cancer using magnetic nanoparticles to recognize molecular target and energy

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Tumor model was achieved by implantation of human breast cancer cell line(BT474, SKBr3) under the fascia of the lower leg of nude mouse. Liposomes bound to antibody could be adjusted and kept stable below 100nm in diameter contained anticancer drugs inside, sealed between lipid bilayer(FeFe204) magnetite. In the group given antibody, chemical and thermal, such systemic therapy showed not only a reduction in tumor size but also a therapeutic effect against the lymph node metastases. As described above, the planned research purposes could be achieved.