Development of a novel minimally invasive treatment of cancer using magnetic nanoparticles to recognize molecular target and energy

使用磁性纳米粒子识别分子靶标和能量开发新型微创癌症治疗方法

• 批准号: 21510116
• 负责人: WATANABE Yuji
• 金额: $ 3.08万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21510116/
• 关键词: 誘導加熱; 温熱療法; モノクロナール抗体; DDS; リポソーム; 化学療法; 蛍光標識; ドセタキセル; 分子標的治療; 温熱化学療法; ナノ磁性粒子; Her2/neu; 発熱磁性体; マグネタイト

Tumor model was achieved by implantation of human breast cancer cell line(BT474, SKBr3) under the fascia of the lower leg of nude mouse. Liposomes bound to antibody could be adjusted and kept stable below 100nm in diameter contained anticancer drugs inside, sealed between lipid bilayer(FeFe204) magnetite. In the group given antibody, chemical and thermal, such systemic therapy showed not only a reduction in tumor size but also a therapeutic effect against the lymph node metastases. As described above, the planned research purposes could be achieved.

肿瘤模型是通过在裸鼠下腿的筋膜下植入人类乳腺癌细胞系（BT474，SKBR3）来实现的。与抗体结合的脂质体可以调节并保持稳定的直径低于100nm的稳定内部含有抗癌药物，并在脂质双层（FEFE204）磁铁矿之间密封。在给定抗体的组中，化学和热疗法，这种全身疗法不仅显示出肿瘤大小的降低，而且还显示出对淋巴结转移的治疗作用。如上所述，可以实现计划的研究目的。

项目成果

Heat Generation Ability in AC Magnetic Field and Their Computer Simulation for Ti Tube Filled with Ferrite Powder

铁氧体粉末填充钛管在交流磁场中的生热能力及其计算机模拟

• 发表时间: 2011
• 期刊: Journal of Magnetism and Magnetic Materials Vol.323
• 作者: H.Aono;T.Naohara;T.Maehara;H.Hirazawa;S.Matsutomo;Y.Watanabe
• 通讯作者: Y.Watanabe

Heat generation ability in AC magnetic field of nano MgFe2O4-based ferrite powder prepared by bead milling

珠磨制备的纳米MgFe2O4基铁氧体粉末在交流磁场中的发热能力

• 发表时间: 2011
• 期刊: Journal of Magnetism and Magnetic Materials
• 影响因子: 2.7
• 作者: H. Aono;T. Naohara;Y. Watanabe
• 通讯作者: Y. Watanabe

Feasibility of chemohyperthermia with docetaxel-embedded magnetoliposomes as minimally invasive local treatment for cancer

• DOI: 10.1002/ijc.24864
• 发表时间: 2010-04-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Yoshida，Motohira;Watanabe，Yuji;Kawachi，Kanji
• 通讯作者: Kawachi，Kanji

Feasibility of tailored, selective and effecive anticancer chemotherapy by direct injection of docetaxel-loaded immunoliposomes into Her2/neu positive gastric tumor xenografts

通过直接注射多西紫杉醇免疫脂质体到 Her2/neu 阳性胃肿瘤异种移植物中进行定制、选择性和有效抗癌化疗的可行性

• 发表时间: 2011
• 期刊: International Journal of Oncology
• 影响因子: 5.2
• 作者: Y.Yamamoto;Y.Watanbe;et al.
• 通讯作者: et al.

Heat generation ability in AC magnetic field of nano MgFe2O4-based ferritfe powder prepared by bead milling

珠磨制备纳米MgFe2O4基铁氧体粉末在交流磁场中的发热能力

• 发表时间: 2011
• 期刊: Journal of Magnetism and Magnetic Materials
• 影响因子: 2.7
• 作者: Koji KIMOTO;Hiromichi Aono
• 通讯作者: Hiromichi Aono