Development of enclosed body of Free-Radical material by way of the efficacious reinforcement at the hyper-thermia therapy for peritonitis carcinomatosa

开发自由基材料封闭体，有效强化癌性腹膜炎热疗

• 批准号: 14571218
• 负责人: KIMURA Akio
• 金额: $ 1.47万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571218/
• 关键词: peritonitis carcinomatosa; hyper-thermia therapy; eicosapentaenoic acid; microsheres; マイクロスフェアー

We already confirmed that chemotherapy using 5-FU suppository, contained poly-unsaturated fatty acid, had the tumorcidal effect with hyper-thermo therapy and radiation therapy at local recurrent of rectal cancer. In this project, we planed that we would develop microsheres contained poly-unsaturated fatty acid, this fatty acid made Free-Radical material affected by hyperthermia, and we would apply for the hyper-thermo-chemo-therapy at the peritonitis carcinomatosa with advance rectal cancer.The eicosapentaenoic acid is poly-unsaturated fatty acid. And it calls Omega-3 fatty acid (or n-3 poly-unsaturated fatty acid). It has preventation of a thrombosis, it is gone down triglyceride, it has anti-inflammation action, and it may suppress cancer. We cannot synthesize it. It is a liquid state at 20℃ or 37℃. We will measure it quantitatively using mono-clonal antibody in vitro, but we measured unstable. We think it cannot keep balance of substance, or stabilizing of mono-clonal antibody. We will add antioxidants or change molecular weight or side chain of poly-unsaturated fatty acid.If we are able to measure poly-unsaturated fatty acid, we will measure transfer rate to lymphoid tissue on the peritoneum at Intraperitoneal injection, and presuppose side effect on other organ.

我们已经证实，使用含有多不饱和脂肪酸的5-FU栓剂进行化疗，在局部复发的直肠癌中具有热疗和放射治疗的杀瘤作用。本课题拟研制含有多不饱和脂肪酸的微粒体，该脂肪酸可作为高温作用下的自由基物质，应用于晚期直肠癌腹膜炎的高温化疗。Omega-3脂肪酸（或n-3多不饱和脂肪酸）。它具有预防血栓形成，降低甘油三酯，具有抗炎作用，并可抑制癌症。我们不能合成它，它在20℃或37℃时是液态。我们将在体外用单克隆抗体进行定量测定，但测定结果不稳定。我们认为它不能保持物质平衡，也不能稳定单克隆抗体。我们将添加抗氧化剂或改变多不饱和脂肪酸的分子量或侧链。如果我们能够测量多不饱和脂肪酸，我们将测量腹膜内注射时向腹膜淋巴组织的转移率，并假设对其他器官的副作用。