Development of enclosed body of Free-Radical material by way of the efficacious reinforcement at the hyper-thermia therapy for peritonitis carcinomatosa

开发自由基材料封闭体，有效强化癌性腹膜炎热疗

• 批准号: 14571218
• 负责人: KIMURA Akio
• 金额: $ 1.47万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571218/
• 关键词: peritonitis carcinomatosa; hyper-thermia therapy; eicosapentaenoic acid; microsheres; マイクロスフェアー

We already confirmed that chemotherapy using 5-FU suppository, contained poly-unsaturated fatty acid, had the tumorcidal effect with hyper-thermo therapy and radiation therapy at local recurrent of rectal cancer. In this project, we planed that we would develop microsheres contained poly-unsaturated fatty acid, this fatty acid made Free-Radical material affected by hyperthermia, and we would apply for the hyper-thermo-chemo-therapy at the peritonitis carcinomatosa with advance rectal cancer.The eicosapentaenoic acid is poly-unsaturated fatty acid. And it calls Omega-3 fatty acid (or n-3 poly-unsaturated fatty acid). It has preventation of a thrombosis, it is gone down triglyceride, it has anti-inflammation action, and it may suppress cancer. We cannot synthesize it. It is a liquid state at 20℃ or 37℃. We will measure it quantitatively using mono-clonal antibody in vitro, but we measured unstable. We think it cannot keep balance of substance, or stabilizing of mono-clonal antibody. We will add antioxidants or change molecular weight or side chain of poly-unsaturated fatty acid.If we are able to measure poly-unsaturated fatty acid, we will measure transfer rate to lymphoid tissue on the peritoneum at Intraperitoneal injection, and presuppose side effect on other organ.

我们已经证实，在直肠癌局部复发时，使用含有多不饱和脂肪酸的5-FU栓剂化疗，与高温治疗和放射治疗具有杀瘤作用。在这个项目中，我们计划开发含有多不饱和脂肪酸的微片，这种脂肪酸使自由基物质受到高温的影响，我们将在晚期直肠癌的腹膜炎癌性腹膜炎中应用高温化疗。二十碳五烯酸是一种多不饱和脂肪酸。它称之为Omega-3脂肪酸（或n-3多不饱和脂肪酸）。它能预防血栓形成，降低甘油三酯，有抗炎作用，还能抑制癌症。我们不能合成它。在20℃或37℃时为液态。我们将使用单克隆抗体在体外定量测量，但我们测量不稳定。我们认为它不能保持物质的平衡，或单克隆抗体的稳定。我们将加入抗氧化剂或改变多不饱和脂肪酸的分子量或侧链。如果我们能够测量多不饱和脂肪酸，我们将测量腹腔注射时向腹膜淋巴组织的转移率，并预先假设对其他器官的副作用。