Analysis of the mechanisms for cytotoxic effects in the perforin/granzyme B system
Analysis of the mechanisms for cytotoxic effects in the perforin/granzyme B system
批准号:
14571221
负责人:
SATO Nobuhiro
金额:
$2.24万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003
中文摘要
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英文摘要
We developed a new assay for cytotoxic effects of perforin/ granzyme B systems, by using Bio Sensor Chip. The assay utilized the surface plasmon resonance technology for the analysis Biomolecular interaction analysis. The assay is rapid and sensitive method, and moreover, allows precise quantitative membranous injury. We also examined inhibitory effects of seine protease inhibitor (Serpin) family to cellular injury. Maspin is a candidate for intra cellular molecule to inhibit granzyme B system. We are now examining for the inhibitor effects by using the RNAi method.
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Oyama M、Terashima M、Takagane A、Maesawa C.:“使用癌胚抗原的定量实时逆转录聚合酶链反应检测胃癌 mRNA 时腹膜微小残留病的预后意义。”Br
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Akiyama Y, Maesawa C, Wada K, Fujisawa K, Itabashi T, Noda Y, Honda T, Sato N, Ishida K, Takagane A, Saito K, Masuda T.: "Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma."Oncol Re. 11(4). 871-874 (2004
Akiyama Y、Maesawa C、Wada K、Fujisawa K、Itabashi T、Noda Y、Honda T、Sato N、Ishida K、Takagane A、Saito K、Masuda T.:“Human PinX1 是一种有效的端粒酶抑制剂,不参与
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Iijima S, Maesawa C, Sato N, Ikeda K, Inaba T, Akiyama Y, Ishida K, Saito K, Masuda T.: "Gastrointestinal stromal tumour of the oesophagus : significance of immunohistochemical and genetic analyses of the c-kit gene."Gastroenterol Hepatol.. 14(4). 445-448
Iijima S、Maesawa C、Sato N、Ikeda K、Inaba T、Akiyama Y、Ishida K、Saito K、Masuda T.:“食管胃肠间质瘤:c-kit 基因免疫组织化学和遗传分析的意义。”
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Nakatani K, Hagihara S, Sando S, Sakamoto S, Yamaguchi K, Maesawa C, Saito I.: "Induction of a remarkable conformational change in a human telomeric sequence by the binding of naphthyridine dimer : inhibition of the elongation of a telomeric repeat by tel
Nakatani K、Hagihara S、Sando S、Sakamoto S、Yamaguchi K、Maesawa C、Saito I.:“通过萘啶二聚体的结合诱导人类端粒序列显着的构象变化:通过抑制端粒重复的延长
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Uchiyama M, Maesawa C, Yashima A, Itabashi T, Ishida Y Masuda T.: "Consensus primers for detecting monoclonal immunoglobulin heavy chain rearrangement in B-cell lymphomas."J Chin Pathol.. 56(10). 778-779 (2003)
Uchiyama M、Maesawa C、Yashima A、Itabashi T、Ishida Y Masuda T.:“用于检测 B 细胞淋巴瘤中单克隆免疫球蛋白重链重排的共有引物。”J Chin Pathol.. 56(10)。
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共 38 条
The "Shohin"as a Domain of No Genre:A Comprehensive Study of its Dynamics and Cultural History
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批准号:20520153
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2008
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负责人:SATO Nobuhiro
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Investigation of pathophysiology and therapeutic strategies for metabolic syndrome-related steatohepatitis
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A Multidisciplinary Study of the Origins and Development of 'Table Talk' in Modern Japan
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财政年份:2003
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负责人:SATO Nobuhiro
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Innate immune response to gut-derived bacterial toxins in gastrointestinal andhepatic disorders
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批准号:12470129
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.36万
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财政年份:2000
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负责人:SATO Nobuhiro
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The analysis of physical stimulation to proliferative gastric cells.
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批准号:08457175
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.86万
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财政年份:1996
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依托单位:
Molecular and cell biological investigation about the healing mechanism of gastric mucosal damage.
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项目类别:Grant-in-Aid for General Scientific Research (B)
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财政年份:1994
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依托单位:
Developmental Research on Preservation of Liver Graft by Improving the Hepatic Microcirculation
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批准号:03454231
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.22万
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财政年份:1991
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负责人:SATO Nobuhiro
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依托单位:
Development of an Endoscopic System for Treating cancerous lesions by Immunological - and medico - technological Modification of Tissue Microcirculation.
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批准号:02557035
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资助金额:$7.68万
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财政年份:1990
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Disturbed Oxygen Metabolism Induced by Perturbation of Microcirculation.
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批准号:01480226
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资助金额:$4.16万
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财政年份:1989
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依托单位:
Dynamic Analysis of Hepatic Microcirculation and Hepatic Function by In vivo-Fluorescence Microscopy -Application to the Study of Pathogenesis and Treatment of Liver Diseases.
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批准号:62480195
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资助金额:$3.2万
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财政年份:1987
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依托单位:
Non-invasive, three-dimensional analysis of hepatic lobular microcirculation.
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批准号:60570319
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资助金额:$1.09万
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财政年份:1985
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负责人:SATO Nobuhiro
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依托单位:
国内基金
海外基金
γδT细胞经Granzyme B/ZO-1通路介导FSGS足细胞损伤的新机制研究
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项目类别:青年科学基金项目(C类)
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批准年份:2021
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负责人:陈婉冰
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依托单位: