OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-up

OCT 在高眼压治疗研究中的应用：20 年随访

• 批准号: 9884415
• 负责人: LINDA M ZANGWILL
• 金额: $ 24.48万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9884415
• 关键词: Address; Age; Agreement; Clinical; Clinical Management; Clinical Trials; Committee Members; Data; Data Analyses; Detection; Development; Diagnosis; Eye; Frequencies; Glaucoma; Image; Incidence; Inner Plexiform Layer; Longitudinal Studies; Measurement; Measures; Modeling; Ocular Hypertension; Onset of illness; Optic Disk; Optical Coherence Tomography; Participant; Patient Outcomes Assessments; Patient Self-Report; Patients; Pattern; Phase; Pilot Projects; Primary Open Angle Glaucoma; Process; Quality of life; Reporting; Reproducibility; Resolution; Resources; Retinal Ganglion Cells; Risk; Scanning; Science; Severities; Specialist; Structure; Surveys; Thick; Thinness; Time; Visit; Visual Fields; age related; base; clinical care; clinical practice; cohort; design; follow-up; ganglion cell; hypertension treatment; improved; macula; normal aging; ocular imaging; older patient; rate of change; retinal nerve fiber layer; standard of care; success; visual optics

Project Summary The “Ocular Hypertension Treatment Study (OHTS 3): 20-year follow-up (Phase 3)” was designed to determine the incidence and severity of primary open angle glaucoma (POAG) in the longstanding OHTS cohort. and determine the frequency and severity of functional limitations associated with POAG. Moreover, this well-characterized cohort has precise information on the dates/timing of the development of POAG assessed by 3 glaucoma specialist endpoint committee members, as well as extensive data on self-reported functional limitations of its participants. Spectral domain optical coherence tomography (OCT), now the standard of care for detecting glaucomatous structural damage and change was included for the first time in OHTS as part of the OHTS 3 core visit. The objective of this secondary data analysis proposal is to analyze the OHTS 3 OCT scans and leverage the 20 years of OHTS data to provide guidance on how best to utilize OCT in the clinical management of glaucoma. Specific Aim 1 will determine whether review of macula scans improves POAG detection compared to the clinical standard review of VF and RNFL scans. With the increased focus on patient-reported outcomes as a key measure of treatment success, in Specific Aim 2 we will utilize the extensive quality of life (QOL) surveys from OHTS 3 and include OCT structural damage in models to predict functional limitations due to POAG. Finally, with a participant median age of 73 years at the OHTS 3 core visit, Specific Aim 3 will characterize structural damage and its determinants 10 and 15 years after the precise onset of POAG and compare it to age-related structural changes in these older subjects who did not develop POAG.

项目总结