The research about overexpression gene identification with neuroblastoma on Biochip

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This research planned to fine overexpression gene of neuroblastoma by using Biochip at first. However, technically, because it was impossible, it decided to identify the gene which participates in the mechanism of spontaneous differentiation and regression with cDNA microarray.Neuroblastoma (NB), one of the most common solid tumors among children, is known found under the age of one year often show spontaneous differentiation and regression. But some shift to unfavorable type and progress to an advance stage with metastasis. Therefore, it is very important to know which tumor will regress or progress. Using histological classified by the degree of maturation, we analyzed gene-expression profiles of 14 NB tumors on coda microarray to elucidate the mechanisms of spontaneous differentiation and regression. Computational analysis identified the gene which has a difference between differentiating NB tumors and poorly differentiated NB tumors. Differentiating NB group included genes associated with cell maturation and apoptosis. Poorly differentiated NB group included in relation to tumorigenesis. The future, examination will be added ; it thinks that we want to be able to lead to development of new therapeutic strategies.