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The significance of adipocyte-drived cytokines in the preventive effect of exercise on atherosclerosis.

脂肪细胞驱动的细胞因子在运动预防动脉粥样硬化中的意义。

基本信息

批准号：
14580059
负责人：
TAKANAMI Yoshikazu
金额：
$ 2.3万
依托单位：
Tokyo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

In this study, we assessed the hypothesis that aerobic exercise training could increase adiponectin, a newly identified adipocyte-drived antiatherogenic plasma protein, in connection with the reduction of body fat, and this increased adiponectin may improve arterial stiffness. We randomly assigned the sedentary middle-aged subjects to two groups : one that enagaged in 30-60 minutes of aerobic exercise at least 3 times a week for 3 months (exercise group), and one age-matched group that underwent no modifications in physical activity (control group). Indices of body fat, serum lipids serum adiponectin levels and brachial-ankle pulse wave velocity (baPWV), index of arterial stiffness, were measured at baseline and after 3 months of exercise training or after 3 months of no modifications in activity (control group). Visceral fat area (VFA) and subcutaneous fat area (SFA) at the umbilical level were determined by computed tomographic scanning. Significant reductions in VFA and SFA were observed following the 3-month excercise training period. Also, there was a significant increase in serum adiponectin levels after the exercising training, however, no significant change was observed in all parameters of the control group. Furthermore, the changes in serum adiponectin levels were correlated with changes in body weeight and VSA as a result of the exercise training. No significant correlation between the changes in serum adiponectin levels and the changes in baPWV was observed after the exercise training. There was a significant correlation between the changes in baPWV and the changes in VFA after the training. From these results, we conclude that a mild aerobic exercise training increase serum adiponectin levels through the reduction of abdominal obesity. The improvement of some factors other than adiponectin in relation to accumulated visceral fat may be resoponsible for the improvement of arterial stiffness after the exercise training.

在这项研究中，我们评估了有氧运动训练可以增加脂联素的假设，脂联素是一种新发现的脂肪细胞驱动的抗动脉粥样硬化血浆蛋白，与体脂减少有关，这种增加的脂联素可能会改善动脉僵硬度。我们将久坐不动的中年受试者随机分为两组：一组每周至少进行3次30-60分钟的有氧运动，持续3个月（运动组），另一组年龄匹配，没有进行任何身体活动（对照组）。在基线和3个月运动训练后或3个月无活动改变后（对照组）测量体脂指数、血脂、血清脂联素水平和臂踝脉搏波速度（baPWV）、动脉硬度指数。通过计算机断层扫描确定脐水平的内脏脂肪面积（VFA）和皮下脂肪面积（SFA）。在3个月的运动训练期后，观察到VFA和SFA显著降低。运动训练后血清脂联素水平显著升高，而对照组各项指标均无显著变化。此外，血清脂联素水平的变化与运动训练后体重和VSA的变化相关。运动训练后血清脂联素水平的变化与baPWV的变化无明显相关性。训练后baPWV的变化与VFA的变化有显著相关性。从这些结果，我们得出结论，轻度有氧运动训练通过减少腹型肥胖增加血清脂联素水平。除脂联素外，与内脏脂肪堆积有关的其他因素的改善可能是运动训练后动脉僵硬度改善的原因。