Can prolonged exercise training enhance the anti-atherogenic function of HDL? - Effect of exercise training on antioxidant properties of HDL -

长时间的运动训练能否增强HDL的抗动脉粥样硬化功能？

• 批准号: 10680052
• 负责人: TAKANAMI Yoshikazu
• 金额: $ 2.37万
• 依托单位: Tokyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680052/
• 关键词: exercise; atherosclerosis; HDL; oxidized LDL; antioxidant; paraoxonase 1

The purpose of this study was to elucidate the effect of exercise training on the antioxidant property of HDL to LDL oxidation. The oxidative susceptibility of serum and LDL decreased significantly after the exercise training. There was a significant correlation between the change in the index of serum oxidative susceptibility and the change in HDL-C.In the group in which either paraoxonase activity or arylesterase activity increased after the exercise training, there was a significantly pronounced decrease of LDL oxidative susceptibility after the program. Furthermore, the change in arylesterase activity was significantly correlated with the change in LDL oxidative susceptibility after the program. In vitro experiment revealed that there was no significant difference between pre-exercise HDL and post-exercise HDL in the preventive effect, examined in the adjusted level of HDL protein, on LDL oxidation. The inhibition of LDL oxidation by HDL might be dependent on the concentration of HDL.From these results, we conclude that exercise-induced elevation of HDL level and HDL-bound PON activity may contribute to the enhanced oxidative resistance of LDL through aerobic exercise training.

本研究旨在阐明运动训练对高密度脂蛋白对低密度脂蛋白氧化的抗氧化作用的影响。运动训练后血清和低密度脂蛋白氧化易感性明显降低。血清氧化易感性指数的变化与高密度脂蛋白胆固醇的变化显著相关，运动后对氧磷酶和芳香酯酶活性升高的组，运动后低密度脂蛋白氧化易感性显著降低。此外，芳香酯酶活性的变化与计划后低密度脂蛋白氧化敏感性的变化显著相关。体外实验表明，运动前和运动后的高密度脂蛋白对低密度脂蛋白氧化的预防作用无显著差异。高密度脂蛋白对低密度脂蛋白氧化的抑制作用可能依赖于高密度脂蛋白的浓度。因此，运动诱导的高密度脂蛋白水平和高密度脂蛋白结合的PON活性的升高可能是有氧运动训练增强低密度脂蛋白抗氧化能力的原因之一。

项目成果

Takanami.Y et al: "Vitamin E supplementation and endurance exercise-Are there benefits?-"Sports Medicine. 29. 73-83 (2000)

Takanami.Y等人：“补充维生素E和耐力运动-有好处吗？-”运动医学。

高波嘉一 他: "中高年者において継続的な運動は酸化ストレスに対する耐性を高めるか?"健康医科学. 15. 16-24 (2000)

Yoshikazu Takanami 等人：“持续运动会增强中老年人对氧化应激的抵抗力吗？” 健康医学科学 15. 16-24 (2000)。

Kawai, Y., Shimomitsu, T., Takanami, Y., Murase, N., Katsumura, T., Maruyama, C.: "Vitamin E level changes in serum and red blood cells due to acute exhaustive exercise in collegiate women"J.Nutr.Sci.Vitaminol.. 46 (2). 119-124 (2000)

Kawai, Y.、Shimomitsu, T.、Takanami, Y.、Murase, N.、Katsumura, T.、Maruyama, C.：“女大学生急性力竭运动导致血清和红细胞中维生素 E 水平的变化”

高波嘉一 他: "運動と酸化LDL"体力科学. 48. 651-660 (1999)

Yoshikazu Takanami 等人：“运动和氧化 LDL”《体能科学》48. 651-660 (1999)

高波嘉一: "中高年者において継続的な運動は酸化ストレスに対する耐性を高めるか?"健康医科学. 15. (2000)

Yoshikazu Takanami：“持续运动会增强中老年人对氧化应激的抵抗力吗？”15. (2000)