Can prolonged exercise training enhance the anti-atherogenic function of HDL? - Effect of exercise training on antioxidant properties of HDL -

本研究的目的是阐明运动训练对HDL到LDL氧化的抗氧化特性的影响。运动训练后血清和LDL的氧化敏感性明显降低。血清氧化易感性指数变化与HDL-C变化有显著相关性。在运动训练后对氧磷酶活性或芳烯酯酶活性增加的那一组中，LDL氧化易感性在训练后显著降低。此外，程序后芳烯酯酶活性的变化与LDL氧化易感性的变化显著相关。体外实验显示，运动前HDL与运动后HDL对LDL氧化的预防作用无显著差异。HDL对LDL氧化的抑制作用可能与HDL的浓度有关。根据这些结果，我们得出结论，运动诱导的HDL水平升高和HDL结合的PON活性可能有助于通过有氧运动训练增强LDL的氧化抗性。

The purpose of this study was to elucidate the effect of exercise training on the antioxidant property of HDL to LDL oxidation. The oxidative susceptibility of serum and LDL decreased significantly after the exercise training. There was a significant correlation between the change in the index of serum oxidative susceptibility and the change in HDL-C.In the group in which either paraoxonase activity or arylesterase activity increased after the exercise training, there was a significantly pronounced decrease of LDL oxidative susceptibility after the program. Furthermore, the change in arylesterase activity was significantly correlated with the change in LDL oxidative susceptibility after the program. In vitro experiment revealed that there was no significant difference between pre-exercise HDL and post-exercise HDL in the preventive effect, examined in the adjusted level of HDL protein, on LDL oxidation. The inhibition of LDL oxidation by HDL might be dependent on the concentration of HDL.From these results, we conclude that exercise-induced elevation of HDL level and HDL-bound PON activity may contribute to the enhanced oxidative resistance of LDL through aerobic exercise training.