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A study on the optimal predictive biomarkers for the effect of exercise-training on prevention of the lifestyle-related disease.

关于运动训练对预防生活方式相关疾病效果的最佳预测生物标志物的研究。

基本信息

批准号：
17300222
负责人：
TAKANAMI Yoshikazu
金额：
$ 8.07万
依托单位：
Kyoto Prefectural University of Medicine (2007)Doshisha University (2006)Tokyo Medical University (2005)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Poor lifestyle habits contribute to underlying lifestyle-related diseases such as metabolic syndrome (MetS) and atherosclerosis, and eventually lead to fatal diseases such as coronary artery disease and cerebrovascular disease. Regular exercise is generally effective for preventing lifestyle-related diseases, and can be made even more effective by adjusting the amount and type of exercise while accurately monitoring its effects in consideration of individual differences. The objective of the present study was to find the optimal biomarker for assessing the effects of exercise. A total of 26 men with MetS or pre-MetS were instructed to engage in exercise at a fitness club twice weekly, and to walk more often and briskly, use the staircase, etc. in their daily lives. Masts were conducted before and after 16 weeks of this exercise intervention. The results showed a mean weight decrease of 6.1kg and a mean decrease in visceral fat area of 28%. In addition, significant improvements were obs … More erved in all test items used as diagnostic criteria for MetS. Significant decreases following exercise intervention were observed for small, dense LDL cholesterol and RLP cholesterol, which are indicators of lipoproteins that are directly involved in the development of atherosclerosis. As these changes varied among individuals, these parameters were considered candidate biomarkers for the effects of exercise. Adiponectin, a useful adipokine, significantly increased and had a significantly positive correlation with the amount of physical activity, and was thus considered a candidate marker. SPARC, a skeletal muscle-derived secretory protein (myokine) that had been identified in animal experiments as a candidate marker, did not significantly change after exercise intervention in the present study. However, FGF21, which has been reported to be an important myokine in glucose metabolism, showed a remarkable reduction, and may thus be a novel biomarker for the effects of exercise. Future expectations are that these novel biomarkers can be used to enable accurate exercise guidance. Less

不良的生活习惯会导致代谢综合征（MetS）和动脉粥样硬化等潜在的生活方式相关疾病，并最终导致冠状动脉疾病和脑血管疾病等致命疾病。定期运动对于预防生活方式相关疾病通常是有效的，并且可以通过调整运动量和类型来提高效果，同时考虑到个体差异准确监测其效果。本研究的目的是找到最佳的生物标志物来评估运动的影响。总共有26名男性MetS或前MetS被指示每周两次在健身俱乐部进行锻炼，并在日常生活中更经常和轻快地行走，使用楼梯等。桅杆进行之前和之后16周的这种运动干预。结果显示，平均体重减轻6.1kg，内脏脂肪面积平均减少28%。此外，显著改善是obs ...更多信息在所有用作MetS诊断标准的检测项目中均有效。在运动干预后，观察到小而密的LDL胆固醇和RLP胆固醇显著降低，这些胆固醇是直接参与动脉粥样硬化发展的脂蛋白的指标。由于这些变化在个体之间存在差异，因此这些参数被认为是运动影响的候选生物标志物。脂联素是一种有用的脂肪因子，显著增加，并与体力活动量呈显著正相关，因此被认为是候选标志物。骨骼肌源性分泌蛋白（肌细胞因子），已被确定在动物实验中作为一个候选标记物，并没有显着改变运动干预后，在本研究中。然而，已被报道为葡萄糖代谢中的重要肌因子的FGF 21显示出显著的减少，因此可能是运动影响的新生物标志物。未来的期望是，这些新的生物标志物可用于实现准确的运动指导。少