A study on the optimal predictive biomarkers for the effect of exercise-training on prevention of the lifestyle-related disease.

不良的生活习惯会导致与生活方式相关的潜在疾病，如代谢综合征（MetS）和动脉粥样硬化，并最终导致冠状动脉疾病和脑血管疾病等致命疾病。有规律的运动通常对预防与生活方式有关的疾病有效，如果在考虑到个体差异的情况下，调整运动量和运动类型，并准确监测其效果，则可以使运动更加有效。本研究的目的是寻找评估运动效果的最佳生物标志物。共有26名患有MetS或MetS前期的男性被要求每周两次在健身俱乐部进行锻炼，并在日常生活中更频繁、更快速地散步，使用楼梯等。在这项运动干预之前和之后进行了16周的测试。结果显示，体重平均减少6.1kg，内脏脂肪面积平均减少28%。此外，作为met诊断标准的所有测试项目均有显著改善。运动干预后观察到小密度LDL胆固醇和RLP胆固醇显著降低，这是直接参与动脉粥样硬化发展的脂蛋白指标。由于这些变化因人而异，这些参数被认为是运动影响的候选生物标志物。脂联素，一种有用的脂肪因子，显著增加，并与体力活动量显著正相关，因此被认为是一个候选标志物。SPARC是一种骨骼肌来源的分泌蛋白（肌因子），在动物实验中被确定为候选标记物，在本研究中，运动干预后没有显着改变。然而，据报道，FGF21在葡萄糖代谢中是一个重要的肌因子，它显示出显著的减少，因此可能是运动影响的一种新的生物标志物。未来的期望是，这些新的生物标志物可以用来实现准确的运动指导。少

Poor lifestyle habits contribute to underlying lifestyle-related diseases such as metabolic syndrome (MetS) and atherosclerosis, and eventually lead to fatal diseases such as coronary artery disease and cerebrovascular disease. Regular exercise is generally effective for preventing lifestyle-related diseases, and can be made even more effective by adjusting the amount and type of exercise while accurately monitoring its effects in consideration of individual differences. The objective of the present study was to find the optimal biomarker for assessing the effects of exercise. A total of 26 men with MetS or pre-MetS were instructed to engage in exercise at a fitness club twice weekly, and to walk more often and briskly, use the staircase, etc. in their daily lives. Masts were conducted before and after 16 weeks of this exercise intervention. The results showed a mean weight decrease of 6.1kg and a mean decrease in visceral fat area of 28%. In addition, significant improvements were obs … More erved in all test items used as diagnostic criteria for MetS. Significant decreases following exercise intervention were observed for small, dense LDL cholesterol and RLP cholesterol, which are indicators of lipoproteins that are directly involved in the development of atherosclerosis. As these changes varied among individuals, these parameters were considered candidate biomarkers for the effects of exercise. Adiponectin, a useful adipokine, significantly increased and had a significantly positive correlation with the amount of physical activity, and was thus considered a candidate marker. SPARC, a skeletal muscle-derived secretory protein (myokine) that had been identified in animal experiments as a candidate marker, did not significantly change after exercise intervention in the present study. However, FGF21, which has been reported to be an important myokine in glucose metabolism, showed a remarkable reduction, and may thus be a novel biomarker for the effects of exercise. Future expectations are that these novel biomarkers can be used to enable accurate exercise guidance. Less