权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Is the improvement of peripheral microcirculation responsible for the beneficial effects of exercise on coronary risk factors?

周围微循环的改善是否是运动对冠状动脉危险因素产生有益影响的原因？

基本信息

批准号：
12680051
负责人：
TAKANAMI Yoshikazu
金额：
$ 1.92万
依托单位：
Tokyo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The purpose of this study was to investigate a hypothesis that the improvement of peripheral microcirculation is responsible for the beneficial effects of exercise on coronary risk factors. Preliminary studyindicated that the measurement of basal forearm blood flow atrest (basal FBF) and total excess blood flow during reactive hyperemia (excess flow: index of NO dependent endotherial function) wereappropriate for evaluation of the improvement of peripheral microcirculation through exercise training. We then investigated the effects of a 3-month aerobic exercise training protocol at low intensity on coronary risk factors, basal FBF and excess flow. Blood glucose,serum insulin level and HOMA-IR (index of insulin resistance) decreased after the exercise training, indicating that glucose metabolismimproved through this mild exercise training. There were significantdecreases of serum TG, RLP-C and RLP-TG levels after the exercisetraining, indicating that TG rich lipoprotein metabolism impro … More ved through this exercise training. However, no significant change in preheparin LPL mass was observed after the exercise training. We further measured basal FBF and excess flow in order to clarify the effectsof exercise training on endothelial function. Basal FBF and excess flow showed no significant change after the exercise training; theimprovement of peripheral microcirculation did not observed as a result of this mild exercise training. Furthermore, there was no significant correlation between the changes in indices of peripheral microcirculation and the changes in coronary risk factors through the exercise training. These results indicated that peripheral microcirculation was not responsible for the improvement of coronary risk factors through this mild aerobic exercise training. Further study using a different exercise training protocol may be required to confirm the relationship between the improvement of peripheral microcirculation through exercise and the beneficial effects of exercise on coronaryrisk factors. Less

本研究的目的是探讨一种假说，即外周微循环的改善是运动对冠状动脉危险因素产生有益影响的原因。初步研究表明，测定前臂基础血流量(基础FBF)和反应性充血时的总过剩血流量(过剩血流量：反映非依赖性血管内皮功能的指标)是评价运动训练对周围微循环改善的适宜指标。然后，我们研究了为期3个月的低强度有氧运动训练方案对冠状动脉危险因素、基础空腹血糖和过量血流量的影响。运动训练后血糖、血清胰岛素水平及胰岛素抵抗指数(HOMA-IR)均有所下降，提示轻度运动训练可改善糖代谢。运动后血清TG、RLp-C和RLp-TG水平显著降低，提示富含TG的脂蛋白代谢促进了…更多的人通过这次运动训练受益匪浅。但运动训练后，肝素前脂蛋白含量无明显变化。为了阐明运动训练对血管内皮功能的影响，我们进一步测量了基础FBF和过量血流量。运动训练后基础空腹血流量和过剩血流量无明显变化；轻度运动训练未见外周微循环改善。此外，运动训练后外周微循环指标的变化与冠脉危险因素的变化之间无显著相关性。这些结果表明，外周微循环不是通过这种轻度有氧运动改善冠状动脉危险因素的原因。可能需要使用不同的运动训练方案进行进一步的研究，以证实运动改善外周微循环与运动对冠心病危险因素的有利影响之间的关系。较少