autonomous distributed control system for totally implantable assist pump sisytem

全植入式辅助泵系统的自主分布式控制系统

• 批准号: 16500299
• 负责人: OKAMOTO Eiji
• 金额: $ 2.37万
• 依托单位: Hokkaido Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500299/
• 关键词: artificial heart; ventricular assist device; fuzzy control; autonomous system; implantable battery; information transmission; early diagnosis; lithium polymer; FPGA; コンプライアンスチャンバ; 自己診断; ニューラルネットワーク; 補助循環; 補助人工心臓; ファージ推論; 適応ノイズフィルタ; ファージ制御

Basic study for realization of adaptation, evolution, and self-diagnosis on an artificial heart has been carried out by an autonomous distributed control system for an ultra-lightweight pulsatile VAD (volume of 285 ml and weight of 360 g). The autonomous distributed control system was built by 4 layers (input layer, measurement layer, control layer, output layer) and an object manager, which was realized on a lchip microcomputer (Hitachi, SH7044, Japan). The control layer consists of 3 autonomous objects: position control, velocity control, and current control. The position and velocity control objects are constructed by fuzzy inference algorism in order to build doctors' and engineers' knowledge into the VAD control. The object manager paces events on each object in order to maintain time series processes.In vitro experiments showed that The VAD has maximum pump outflow of 5.1 L/min against afterload of 100 mmHg under control of our autonomous control system.The self-diagnosis has been realized by a neural network based early diagnosis system using artificial heart sound. A long-term animal experiment showed that the early diagnosis system automatically and successfully had detected malfunction of pump 24 hours before pump stoppage.The above results show that our VAD system promises possibility as a new superior artificial heart system.

为实现人工心脏的适应，进化和自我诊断的基础研究已经进行了自主分布式控制系统的超轻型脉动VAD（体积为285毫升，重量为360克）。自治分布式控制系统由4层（输入层、测量层、控制层、输出层）和一个对象管理器组成，在日本日立SH 7044单片机上实现。控制层由3个自主对象组成：位置控制、速度控制和电流控制。采用模糊推理算法构造位置和速度控制对象，将医生和工程师的知识融入到VAD控制中。体外实验表明，在自主控制系统的控制下，VAD在100 mmHg的后负荷下，最大泵流量为5.1 L/min，利用人工心音实现了基于神经网络的早期诊断系统的自诊断。长期的动物实验表明，该系统在停泵前24小时自动检测到泵的故障，表明该系统有望成为一种新型的上级人工心脏系统。

项目成果

Development of Integrated Electronic Unit for Drive and Control of Undulation Pump LVAD

波动泵LVAD驱动与控制集成电子单元的研制

• 发表时间: 2006
• 期刊: Artificial Organs 30・5
• 作者: E.Okamoto;T.Makino;S.Tanaka;T.Yasuda;Y.Akasaka;M.Tani;Y.Inoue;A.Mitoh;Y.Mitamura;E.Okamoto;E.Okamoto;E.Okamoto;E.Okamoto;E.Okamoto
• 通讯作者: E.Okamoto

Development of implantable assist pump and its peripheral devices

植入式辅助泵及其周边装置的研制

• 发表时间: 2006
• 期刊: Biocybernetics and Biomedical Engineering 26・1
• 作者: T.Motomura;H.Okubo;T.Oda;D.Ogawa;T.Okahira;S.Igo;T.Shinohara;Y.Yamamoto;C.Noguchi;T.Ishizuka;E.Okamoto;Y.Nose;E.Okamoto;E.Okamoto;E.Okamoto;T.Makino;E.Okamoto et al.
• 通讯作者: E.Okamoto et al.

全固体二次電池の要素技術(第1章3節 医療分野における薄膜、小型電池技術と要求特性

全固态二次电池的基本技术（第一章第三节薄膜和小型电池技术以及医疗领域所需的特性

• 发表时间: 2007
• 作者: Y.Mitamura;K.Kido;T.Yano;D.Sakota;R.Yozu;E.Okamoto;S.Murabayashi;I.Nishimura;岡本英治;岡本 英治
• 通讯作者: 岡本 英治

A Hydrodynamically suspended magnetically sealed mechanically noncontact axial flow blood pump : design of a hydrodynamic bearing.

流体动力悬浮磁密封机械非接触式轴流血泵：流体动力轴承的设计。

• 发表时间: 2007
• 期刊: Artificial Organs 31(3)
• 作者: Y.Mitamura;K.Kido;T.Yano;D.Sakota;T.Yambe;K.Sekine;E.Okamoto
• 通讯作者: E.Okamoto

Ten-year NEDO BVAD Development Program : Moving Forward to the Clinical Arena.

十年 NEDO BVAD 开发计划：迈向临床舞台。

• 发表时间: 2006
• 期刊: J.ASAIO 52(4)
• 作者: T.Motomura;H.Okubo;T.Oda;D.Ogawa;T.Okahira;S.Igo;T.Shinohara;Y.Yamamoto;C.Noguchi;T.Ishizuka;E.Okamoto;Y.Nose
• 通讯作者: Y.Nose