Life style intervention in metabolically obese with normal-weight subject selected in general population of Mihama district.

代谢综合征是一种病理状态，可引起血管并发症，如心肌梗死和脑梗死。内脏脂肪堆积是最重要的致病因素，是日本代谢综合征标准诊断的必要条件。最近我们报道了非肥胖受试者（BMI < 25 kg/m^2）在脐部CT扫描测量的内脏脂肪面积大于100 cm2时表现出类似肥胖代谢综合征的代谢异常。这一群体通常被称为“正常体重代谢肥胖（MONW）”。在我们的研究中，人口是来自三重县三滨镇的MONW受试者，研究的目的是调查对生活方式的影响。我们检查了他们在改变饮食和运动前后的腹围和代谢参数。829人（男/女：288/541）在三滨市参加了我们的糖尿病检查，其中32名男性被选为MONW受试者，但没有女性患有MONW。我们举办了一个关于代谢综合征的研讨会，对生活方式进行干预。7名MONW和2名肥胖受试者参加了这个项目。在干预之前，对他们的生活方式进行了检查。能量消耗、盐和铁的摄入量是适当的。然而，蛋白质和脂肪摄入过量，碳水化合物和膳食纤维和钙摄入不足。此外，我们调查了脂肪摄入量、脂肪能量%、饱和脂肪酸摄入量、n3和n6脂肪酸摄入量的细节，都是合适的。基于上述数据的干预方案目前正在进行中。此外，我们正在尽一切可能增加MONW和肥胖代谢综合征组的受试者数量，以阐明通过改变生活方式改善代谢异常的效果是否会影响氧化应激和不平衡的脂肪因子网络。

Metabolic syndrome is a pathological condition that may cause vascular complications such as myocardial infarction and cerebral infarction. Accumulation of visceral fat is the most important causative factor and it is essential for its diagnosis by the Japanese criteria of metabolic syndrome. Recently we have reported that non-obese subjects (BMI < 25 kg/m^2) with visceral fat area measured by CT scan at the umbilical level are more than 100 cm2 show metabolic abnormalities similar to obese metabolic syndrome. This group is commonly called 'metabolically obese with normal-weight (MONW)'. In our study, the population was MONW subjects from Mihama town of Mie prefecture and the purpose of the study was to investigate influence on life style. We examined abdominal circumference and metabolic parameters before and after the modification of their diet and exercise.Eight hundred and twenty nine people (male/female: 288/541) visited our diabetic examination in Mihama, and 32 men were selected as MONW subjects, but there were no women with MONW. We held a workshop about metabolic syndrome to perform an intervention program in life style. 7 MONW and 2 obese subjects were enrolled in this program. Before intervention, their life styles were examined. Energy expenditure, salt and iron intake were appropriate. However, protein and fat intake were excessive, and carbohydrate and dietary fiber and calcium intake were deficient. Furthermore, we investigated the details regarding fat intake, energy % of fat, saturated fatty acid intake, n3 and n6 fatty acid intake, all of them were found to be appropriate. This intervention program based on the above data is now in progress. Moreover, we are making all possible effort to increase the number of the subjects in MONW and obese metabolic syndrome group to elucidate whether the effect of improvement of metabolic abnormalities by modifying life style affects oxidative stress and the unbalanced adipokine network.