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Development of the supporting system for the patients with multiple risk factors by exercise therapy

多重危险因素患者运动疗法支持系统的构建

基本信息

批准号：
16500445
负责人：
SHONO Naoko
金额：
$ 2.3万
依托单位：
Saga University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500445/
关键词：
Multiple risk factor Exercise therapy Lactate threshold Exercise prescription Metabolic Syndrome Postprandial metabolism Metabolic Sx 継続支援肥満 Multiple risk factor 乳酸閾値変形性膝関節症高感度CRP

项目摘要

1) Postprandial glucose and lipid metabolism and exercise therapyHigh sensitive C-reactive protein may be a predictive marker in high risk obese women, because it is independently associated with both fasting and postprandial free fatty acid and postprandial insulin level. Mild intensity exercise therapy improves postprandial blood profiles even after normal fat meal in obese subjects.2) Determination of the optimal exercise intensityThe work rate at the Lactate threshold (LT) showed significant correlation with the number of risk fatocrs. LT is a safe intensity where ST segment depression has not occurred. Insulin resistance may involve the pathological ST depression during exercise.The estimated target heart rate during exercise has been determined from age, however we suggest that their risk factors should be taken into consideration. Futhermore, careful modification in the prescribed exercise regimen is needed according to improvement in the fitness and in risk factors.The breaking point in double product (DPBP) could be successfully detected in men and women with or without metabolic syndrome. The %BW at the DPBP was suggested to be a useful and reliable index for both an appropriate exercise prescription on a cycle ergometer as well as tracking the temporal trends in physical and metabolic fitness.The exercise prescription in the patients with both osteoarthritis of the knee and multiple risk factors should be lower than that for the patients without osteoarthritis.3) Mechanism and process of impairment and improvement in multiple risk factors by physical fitness.The change in the monocyte and neutrophil counts are associated with the inprovement in both fasting and postprandial triglyceride and aerobic capacity. In the process of the change in the risk factors in obese subjects, the improvement in the fitness and metabolic conditions precede to the changes in body weight.

1)餐后糖脂代谢与运动治疗超敏C反应蛋白与空腹、餐后游离脂肪酸及餐后胰岛素水平均独立相关，可作为高危肥胖妇女的预测指标。轻度运动治疗可以改善肥胖者餐后的血液状况，即使在正常脂肪餐后也是如此。2）最佳运动强度的确定乳酸阈值（LT）下的功率与危险脂肪数显著相关。LT是未发生ST段压低的安全强度。胰岛素抵抗可能与运动时病理性ST段压低有关，运动时的目标心率估计值由年龄决定，但我们建议应考虑其危险因素。然而，需要根据健身和危险因素的改善，仔细修改规定的运动方案。在有或没有代谢综合征的男性和女性中，可以成功地检测到双产品断裂点（DPBP）。DPBP时的%BW被认为是一个有用和可靠的指标，既可以在自行车测力计上制定适当的运动处方，也可以跟踪身体和代谢健康的时间趋势。同时患有膝关节骨关节炎和多种危险因素的患者的运动处方应低于无骨关节炎的患者。3）体质对多种危险因素的损害和改善的机制和过程单核细胞和中性粒细胞计数的变化与空腹和餐后甘油三酯和有氧能力的改善有关。在肥胖者危险因素的变化过程中，体质和代谢状况的改善先于体重的变化。