Evaluation of aortic wall assessed by strain rate in exercise therapy and drug medication

运动疗法和药物治疗中应变率评估主动脉壁的评价

• 批准号: 16500463
• 负责人: KIMURA Yutaka
• 金额: $ 2.3万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500463/
• 关键词: Tissue doppler echocardiography; Exercise Therapy; aortic wall compliance; 超音波組織ドップラ; 大動脈コンプライアンス; 脈波伝搬速度; 有酸素運動

Background : Although brachial-ankle pulse wave velocity (PWV) is a widely used index of arterial stiffness, there are several limitations of this method. The actual length of an artery used for measuring PWV is estimated based on an anatomical correction value, and brachial-ankle PWV is directly affected by systemic blood pressure or vascular occlusion. Thus, the aim of this study to determine whether aortic wall strain rate as measured by tissue Doppler echocardiography is a more useful modality for evaluating regional aortic compliance than brachial-ankle PWV. Methods: Seventy-two patients (18- to 79- years- old) with normal cardiac function and without large vessel complications were enrolled in this study. Results : A significant positive correlation was found between brachial-ankle PWV and age, and brachial-ankle PWV increased with age (r=0.73, p<0.05). A significant negative correlation was found between strain rate and age, and strain rate decreased with age (r=-0.44, p<0.05). A significant correlation also was found between brachial-ankle PWV and systolic blood pressure (r=0.45, p<0.001), but not between strain rate and systolic blood pressure. There was no significant difference in brachial-ankle PWV between hyperlipidemic and normolipidemic subjects. However, strain rate was lower in hyperlipidemic than in normolipidemic subjects (p<0.05). Conclusion : Strain rate on the ascending aortic wall is a novel and more accurate index of regional main aortic wall compliance than brachial-ankle PWV.

背景：虽然臂踝脉搏波速度（PWV）是广泛使用的动脉僵硬度指标，但该方法存在一些局限性。用于测量PWV的动脉的实际长度是根据解剖校正值估计的，臂踝PWV直接受全身血压或血管闭塞的影响。因此，本研究的目的是确定组织多普勒超声心动图测量的主动脉壁应变率是否是比臂踝 PWV 更有用的评估区域主动脉顺应性的方法。方法：72 例心功能正常且无大血管并发症的患者（18 至 79 岁）纳入本研究。结果：臂踝PWV与年龄呈显着正相关，且臂踝PWV随年龄增加而增大（r=0.73，p<0.05）。应变率与年龄呈显着负相关，且应变率随着年龄的增长而降低（r=-0.44，p<0.05）。臂踝 PWV 与收缩压之间也发现显着相关性（r=0.45，p<0.001），但应变率与收缩压之间不存在显着相关性。高脂血症和正常脂血症受试者的臂踝 PWV 无显着差异。然而，高脂血症受试者的应变率低于血脂正常受试者（p<0.05）。结论：升主动脉壁应变率是一种新颖且比臂踝 PWV 更准确的局部主动脉壁顺应性指标。