Comparative investigation of lipid binding proteins of parasitic nematodes from the genus Trichinella

旋毛虫属寄生线虫脂质结合蛋白的比较研究

• 批准号: 47080161
• 负责人: Professorin Dr. Eva Liebau
• 金额: --
• 依托单位: Institut für Integrative Zellbiologie und Physiologie (IIZP)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/47080161?language=en
• 关键词: Comparative; investigation; lipid; binding; proteins

Trichinellosis, caused by parasitic nematodes of the genus Trichinella is still present in Europe, especially in Eastern Europe, where hundreds of human trichinellosis cases occur yearly. Among the allergens produced by parasitic nematodes are the Lipid Binding Proteins (LBPs). The high levels of hydrophobic binding proteins in helminths, together with their restricted lipid metabolism suggests that these proteins play an important role in metabolism and, as such, are putative targets for chemotherapy and vaccine development. The objective of the proposal is to obtain functional, structural and immunological information about Trichinella LBPs using molecular, biochemical and structural methods. The project will improve the understanding of lipid transport mechanisms in nematodes and their role in parasite-host interactions.

由旋毛虫属寄生线虫引起的旋毛虫病仍然存在于欧洲，特别是在东欧，那里每年发生数百例人类旋毛虫病病例。在由寄生线虫产生的过敏原中，有脂质结合蛋白（LBP）。蠕虫中高水平的疏水结合蛋白，以及它们受限的脂质代谢表明，这些蛋白质在代谢中起重要作用，因此，是化疗和疫苗开发的假定靶点。该提案的目的是利用分子、生物化学和结构方法获得旋毛虫LBP的功能、结构和免疫学信息。该项目将提高对线虫脂质转运机制及其在寄生虫-宿主相互作用中的作用的理解。