Study on the System Detecting the Effect of the Molecular-Targeting Therapy for Leukemia and the Patients Prognosis.

白血病分子靶向治疗效果及患者预后检测系统的研究。

• 批准号: 16590448
• 负责人: NARA Nobuo
• 金额: $ 2.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590448/
• 关键词: Leukemia; Molecular-Targeting Therapy; Notch Ligand; Leukemia Cell Line

1. System Detecting the Effect of Molecular-Targeting Therapy for Leukemia.We have established leukemia cells lines that proliferate autonomously producing granulocyte-colony-stimulating factor (G-CSF) or granulocyte-macrophage-colony-stimulating factor (GM-CSF). Using these cell lines, we have examined the effects of antileukemic drugs and molecular-targeting drugs, imatinib and all-trans retinoic acid.2. Study on the Effect of Notch-ligands on Leukemia Cells.Notch-ligands have been shown to activate the self-renewal of stem cells. We have studied on the effects of some Notch-ligands on the leukemia cells from established cell lines and the cell obtained from the freshly diagnosed patient. Notch-ligands showed various effect on leukemia cells. In some cases Notch-ligands have been shown to be involved in the leukemia growth.3. Relationship between the in vitro Effect of Antileukemic Therapy on Leukemia Cells and the Patients Prognosis.After studying the effect on leukemia cells growth in vitro, we have followed the prognosis of the patients to determine the relationship between the in vitro effect and clinical effectiveness.

1.白血病分子靶向治疗效果的系统检测我们已经建立了白血病细胞系，其自主增殖产生粒细胞集落刺激因子（G-CSF）或粒细胞-巨噬细胞集落刺激因子（GM-CSF）。使用这些细胞系，我们已经检查了抗白血病药物和分子靶向药物伊马替尼和全反式维甲酸的作用。Notch配体对白血病细胞作用的研究Notch配体已被证明能激活干细胞的自我更新。我们已经研究了一些Notch配体对来自已建立的细胞系的白血病细胞和从新诊断的患者获得的细胞的作用。Notch配体对白血病细胞有不同的作用。在某些情况下，Notch配体已被证明参与白血病的生长。体外抗白血病治疗对白血病细胞的影响与患者预后的关系在研究了体外抗白血病治疗对白血病细胞生长的影响后，我们跟踪了患者的预后，以确定体外抗白血病治疗效果与临床疗效的关系。

项目成果

血液/腫瘍学シークレット

血液学/肿瘤学的秘密

• 发表时间: 2004
• 作者: Shimamura;N.et al.;Fumiko Terasawa;奈良信雄 監訳
• 通讯作者: 奈良信雄 監訳

The Notch ligand, Delta-1, alters retinoic acid (RA)-induced neutrophilic differentiation into monocytic and reduces RA-induced apoptosis in NB4 cells

• DOI: 10.1016/j.leukres.2004.05.020
• 发表时间: 2005-02-01
• 期刊: LEUKEMIA RESEARCH
• 影响因子: 2.7
• 作者: Murata-Ohsawa, M;Tohda, S;Nara, N
• 通讯作者: Nara, N

Effect of Notch ligands on in vitro sensitivity to chemotherapeutic drugs in leukemia and lymphoma cells

Notch配体对白血病和淋巴瘤细胞体外化疗药物敏感性的影响

• 发表时间: 2005
• 期刊: Oncology Reports 14
• 作者: Kogoshi H;Tohda S;Fu L;Nara N
• 通讯作者: Nara N

Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines

Notch 配体 Delta-1 和 Jagged-1 在两种髓系白血病细胞系中诱导生长抑制的细胞分析

• 发表时间: 2004
• 期刊: International Journal of Molecular Medicine 14
• 作者: Murata-Ohsawa M;Tohda S;Nara N
• 通讯作者: Nara N

造血薬・分子標的抗腫瘍薬の正しい使い方

正确使用造血药物和分子靶向抗肿瘤药物

• 发表时间: 2004
• 期刊: レジデントノート 6巻3号
• 作者: Komiya;T.et al.;奈良信雄
• 通讯作者: 奈良信雄